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Gene Review

Gbeta76C  -  G protein beta-subunit 76C

Drosophila melanogaster

Synonyms: CG8770, DGqbeta, Dmel\CG8770, G[[beta76C]], G[[beta]], ...
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High impact information on Gbeta76C


Biological context of Gbeta76C

  • Remarkably, all three nonvisual B exons are highly similar (82% identity at the amino acid level) to the Gq alpha family consensus, from Caenorhabditis elegans to human, but all three visual A exons are divergent (61% identity) [5].
  • Although the role of the G alpha subunit in effector activation, guanine nucleotide exchange and GTP hydrolysis has been well studied, the cellular functions of the G beta subunits are less well understood [2].
  • Tn-Gbeta shares approximately 90% amino acid sequence identity with Gbeta from Drosophila melanogaster and 84% identity with mammalian Gbeta (human Gbeta1) [6].

Associations of Gbeta76C with chemical compounds

  • Reconstitution of purified GTPgammaS-bound soluble squid Gq with PLC-70 resulted in significant enhancement of PIP2 hydrolysis over a range of Ca2+ concentrations and shifted the maximum activation by calcium to 1 microM [7].

Physical interactions of Gbeta76C

  • In the transgenic flies, mutated Ggammae forms a dimeric complex with Gbetae, with the consequence that the fraction of non-membrane-bound Gbetagamma is increased [8].
  • G beta gamma dimers bind G alpha subunits and anchor them to the membrane for presentation to the receptor [2].

Regulatory relationships of Gbeta76C

  • We have previously purified a 140-kDa PLC enzyme from squid photoreceptors that is regulated by squid Gq [7].

Other interactions of Gbeta76C

  • Despite similarities in the primary structure between the transducin gamma subunit and Drosophila Ggammae, we observed no interaction of human Ggammarod with Drosophila Gbetae [8].
  • A G protein beta subunit gene (Gbe) is expressed only in the eyes of adult D. melanogaster [9].
  • These results suggest that cephalopod phototransduction is mediated by Gq activation of more than one cytosolic PLC enzyme [7].

Analytical, diagnostic and therapeutic context of Gbeta76C

  • Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker [5].
  • Immunocytochemical and in situ hybridization analyses further demonstrate that Gbe is expressed in the eyes but not in the brain, whereas Gbb is abundantly expressed in the brain [9].


  1. Mediation of PACAP-like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in Drosophila. Zhong, Y. Nature (1995) [Pubmed]
  2. An eye-specific G beta subunit essential for termination of the phototransduction cascade. Dolph, P.J., Man-Son-Hing, H., Yarfitz, S., Colley, N.J., Deer, J.R., Spencer, M., Hurley, J.B., Zuker, C.S. Nature (1994) [Pubmed]
  3. Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors. Elia, N., Frechter, S., Gedi, Y., Minke, B., Selinger, Z. J. Cell Biol. (2005) [Pubmed]
  4. Direct activation of trpl cation channels by G alpha11 subunits. Obukhov, A.G., Harteneck, C., Zobel, A., Harhammer, R., Kalkbrenner, F., Leopoldt, D., Lückhoff, A., Nürnberg, B., Schultz, G. EMBO J. (1996) [Pubmed]
  5. Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker. Alvarez, C.E., Robison, K., Gilbert, W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Cloning and characterization of the G protein betagamma subunits from Trichoplusia ni (High Five cells). Vadakkadathmeethal, K., Felczak, A., Davignon, I., Collins, J., Sunahara, R.K. Insect Biochem. Mol. Biol. (2005) [Pubmed]
  7. Purification, G protein activation, and partial amino acid sequence of a novel phospholipase C from squid photoreceptors. Mitchell, J., Mayeenuddin, L.H. Biochemistry (1998) [Pubmed]
  8. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. Schillo, S., Belusic, G., Hartmann, K., Franz, C., Kühl, B., Brenner-Weiss, G., Paulsen, R., Huber, A. J. Biol. Chem. (2004) [Pubmed]
  9. A G beta protein in the Drosophila compound eye is different from that in the brain. Yarfitz, S., Niemi, G.A., McConnell, J.L., Fitch, C.L., Hurley, J.B. Neuron (1991) [Pubmed]
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