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Gene Review

Ggamma1  -  G protein gamma 1

Drosophila melanogaster

Synonyms: CG8261, D-G[[gamma]]1, Dmel\CG8261, G1, G[[gamma1]], ...
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Disease relevance of Ggamma1


High impact information on Ggamma1


Biological context of Ggamma1

  • We identified here the first Drosophila mutant in the Ggamma1 subunit of heterotrimeric G protein, which produces Ggamma1 lacking its membrane anchor site and exhibits phenotypes identical to those of Gbeta13F, including abnormal spindle asymmetry and spindle orientation in NB divisions [3].
  • Genomic Southern blot hybridization indicated that the Drosophila genome has only one D-G gamma 1 gene [5].
  • The spatial expression pattern determined for Ggamma(e) as well as co-immunoprecipitation experiments demonstrated that Ggamma(e) dimerizes with Gbeta(e) to form the heterodimeric Gbetagamma subunit which functions in visual transduction in the Drosophila compound eye [6].
  • The Galpha and Gbetagamma components of heterotrimeric G proteins, typically associated with cell-surface receptor signaling, also partake in the macromolecular interactions that underlie cell polarity and cell division [7].

Anatomical context of Ggamma1


Associations of Ggamma1 with chemical compounds


Other interactions of Ggamma1

  • This phenotype resulted from mutations in the genes encoding HMG-CoA reductase, downstream enzymes in the mevalonate pathway, and G protein Ggamma1, which is geranylgeranylated, thus representing an end point of isoprenoid biosynthesis [1].
  • GPCRs act on inactive Galpha.GDP/Gbetagamma heterotrimers to promote GDP release and GTP binding, resulting in liberation of Galpha from Gbetagamma [8].

Analytical, diagnostic and therapeutic context of Ggamma1

  • Nucleotide (nt) sequence analysis showed that the 70-amino-acid polypeptide encoded by the 1.3-kb transcript of D-G gamma 1 is the same as that encoded by the 1.1- and 2.6-kb D-G gamma 1 transcripts reported earlier [Ray and Ganguly, J. Biol. Chem. 267 (1992) 6086-6092] [9].


  1. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Yi, P., Han, Z., Li, X., Olson, E.N. Science (2006) [Pubmed]
  2. G-protein gamma subunit 1 is required for sugar reception in Drosophila. Ishimoto, H., Takahashi, K., Ueda, R., Tanimura, T. EMBO J. (2005) [Pubmed]
  3. Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division. Izumi, Y., Ohta, N., Itoh-Furuya, A., Fuse, N., Matsuzaki, F. J. Cell Biol. (2004) [Pubmed]
  4. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. Schillo, S., Belusic, G., Hartmann, K., Franz, C., Kühl, B., Brenner-Weiss, G., Paulsen, R., Huber, A. J. Biol. Chem. (2004) [Pubmed]
  5. The Drosophila G protein gamma subunit gene (D-G gamma 1) produces three developmentally regulated transcripts and is predominantly expressed in the central nervous system. Ray, K., Ganguly, R. J. Biol. Chem. (1992) [Pubmed]
  6. A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. Schulz, S., Huber, A., Schwab, K., Paulsen, R. J. Biol. Chem. (1999) [Pubmed]
  7. The GoLoco motif: heralding a new tango between G protein signaling and cell division. Kimple, R.J., Willard, F.S., Siderovski, D.P. Mol. Interv. (2002) [Pubmed]
  8. G-protein signaling: back to the future. McCudden, C.R., Hains, M.D., Kimple, R.J., Siderovski, D.P., Willard, F.S. Cell. Mol. Life Sci. (2005) [Pubmed]
  9. Organization and expression of the Drosophila melanogaster D-G gamma 1 gene encoding the G-protein gamma subunit. Ray, K., Ganguly, R. Gene (1994) [Pubmed]
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