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Gene Review

CTSS  -  cathepsin S

Canis lupus familiaris

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High impact information on CTSS

  • These parameters are important for understanding the role of cathepsin S in different species and for testing inhibitors in animal models of autoimmunity [1].
  • CLINICAL RELEVANCE: These findings suggest that MMP-2, -9, cathepsin S, and TRAP may be important mediators of progressive joint destruction in dogs with CCL rupture [2].
  • Similar to MMP-9, expression of tartrate-resistant acid phosphatase (TRAP) and cathepsin S was only found in stifle tissues from dogs with ruptured CCL; in contrast, expression of cathepsin K was found in all ruptured and intact CCL [2].

Biological context of CTSS

  • CONCLUSION: Rupture of the CCL is associated with up-regulation of expression of MMP-2 and -9 (gelatinase A and B), TRAP, and cathepsin S, and increased degradation of collagen [2].


  1. Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S. Baker, S.M., Karlsson, L., Thurmond, R.L. Protein Expr. Purif. (2003) [Pubmed]
  2. Collagenolytic protease expression in cranial cruciate ligament and stifle synovial fluid in dogs with cranial cruciate ligament rupture. Muir, P., Danova, N.A., Argyle, D.J., Manley, P.A., Hao, Z. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (2005) [Pubmed]
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