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Gene Review

CTSS  -  cathepsin S

Bos taurus

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Disease relevance of CTSS


High impact information on CTSS


Biological context of CTSS


Anatomical context of CTSS


Associations of CTSS with chemical compounds

  • The purification procedure of cathepsin S includes acid activation of spleen homogenate, incubation at 37 degrees C, precipitation with (NH4)2SO4 in H2O/tert-butanol medium, gel chromatography, chromatofocusing, covalent chromatography and cation chromatography of FPLC system [5].

Enzymatic interactions of CTSS

  • A significant characteristic of cathepsin S is that it can hydrolyze insoluble elastin at both acidic and neutral pH; this distinguishes it from all of the other lysosomal proteinases [8].
  • They could however be distinguished by the fact that cathepsin S reacted with Z-[125I]Tyr-Ala-CHN2 and hydrolyzed Z-Phe-Arg-NHMec whereas cathepsin H did not [8].

Analytical, diagnostic and therapeutic context of CTSS

  • Using polymerase chain reaction (PCR) technology, cDNA clones commencing at amino acid 22 of the mature enzyme and continuing through the 3' untranslated region of bovine cathepsin S mRNA were isolated and sequenced [6].


  1. Cathepsin S. The cysteine proteinase from bovine lymphoid tissue is distinct from cathepsin L (EC Kirschke, H., Schmidt, I., Wiederanders, B. Biochem. J. (1986) [Pubmed]
  2. Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins. Kirschke, H., Wiederanders, B., Brömme, D., Rinne, A. Biochem. J. (1989) [Pubmed]
  3. Kinetics of inhibition of bovine cathepsin S by bovine stefin B. Turk, B., Colić, A., Stoka, V., Turk, V. FEBS Lett. (1994) [Pubmed]
  4. The complete amino acid sequence of bovine cathepsin S and a partial sequence of bovine cathepsin L. Ritonja, A., Colić, A., Dolenc, I., Ogrinc, T., Podobnik, M., Turk, V. FEBS Lett. (1991) [Pubmed]
  5. Bovine cathepsins S and L: isolation and amino acid sequences. Dolenc, I., Ritonja, A., Colić, A., Podobnik, M., Ogrinc, T., Turk, V. Biol. Chem. Hoppe-Seyler (1992) [Pubmed]
  6. Primary structure of bovine cathepsin S. Comparison to cathepsins L, H, B and papain. Wiederanders, B., Broemme, D., Kirschke, H., Kalkkinen, N., Rinne, A., Paquette, T., Toothman, P. FEBS Lett. (1991) [Pubmed]
  7. Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation. Rose, C.M., Qian, L., Hakim, L., Wang, Y., Jerdeva, G.Y., Marchelletta, R., Nakamura, T., Hamm-Alvarez, S.F., Mircheff, A.K. Scand. J. Immunol. (2005) [Pubmed]
  8. The specificity and elastinolytic activities of bovine cathepsins S and H. Xin, X.Q., Gunesekera, B., Mason, R.W. Arch. Biochem. Biophys. (1992) [Pubmed]
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