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Gene Review

AT4G11310  -  putative cysteine proteinase

Arabidopsis thaliana

Synonyms: AtCP1, CP1, F8L21.100, F8L21_100, cysteine protease 1
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High impact information on RD21

  • Using one-step affinity capture of biotinylated proteases followed by sequencing mass spectrometry, we identified proteases that include xylem-specific XCP2, desiccation-induced RD21, and cathepsin B- and aleurain-like proteases [1].
  • Arabidopsis RD21 is a cysteine protease of the papain family [2].
  • Subcellular fractionation of the Bright-Yellow 2 transformant showed that the intermediate and mature forms of RD21 were localized in the vacuoles [2].
  • Unlike other members of the papain family, RD21 has a C-terminal extension sequence composed of two domains, a 2-kD proline-rich domain and a 10-kD domain homologous to animal epithelin/granulin family proteins [2].
  • Taken together, these results indicate that the intermediate of RD21 was accumulated in the vacuoles as an aggregate, and then slowly matured to make a soluble protease by removing the granulin domain during leaf senescence [2].


  1. Activity profiling of papain-like cysteine proteases in plants. van der Hoorn, R.A., Leeuwenburgh, M.A., Bogyo, M., Joosten, M.H., Peck, S.C. Plant Physiol. (2004) [Pubmed]
  2. A slow maturation of a cysteine protease with a granulin domain in the vacuoles of senescing Arabidopsis leaves. Yamada, K., Matsushima, R., Nishimura, M., Hara-Nishimura, I. Plant Physiol. (2001) [Pubmed]
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