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Gene Review

Ctss  -  cathepsin S

Rattus norvegicus

Synonyms: Cathepsin S
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High impact information on Ctss


Biological context of Ctss


Associations of Ctss with chemical compounds

  • Epoxy succinate peptide derivatives, CLIK-066, 088, 112, 121, 148, 181, 185 and 187, are typical specific inhibitors for cathepsin L. Aldehyde derivatives CLIK-060 and CLIK-164 showed specific inhibition against cathepsin S and cathepsin K, respectively [6].
  • To see the physiological role these enzymes play in the brain, we studied the relative abundance and distribution of the messenger RNAs for three lysosomal cysteine proteases, cathepsins B and L and cathepsin S, by in situ hybridization histochemistry in rat brain [7].
  • In nephron segments microdissected from lyophilized renal sections, highest cathepsin S activity was found in the proximal convoluted tubules (4.21 mumol/min x g dry weight) followed by 0.83 mumol/min x g dry weight in proximal straight tubules of the superficial cortex [8].
  • The stability of cathepsin S at pH 7.5 and the resistance of cathepsin B against inactivation by 0.5 microM Z-Phe-Phe-CHN2 permitted differentiation of these enzyme activities [8].
  • New synthetic pyridoxal propionate derivatives, -162, -163, and -164, in which the methyl arm of position 6 of CLIK-071 was additionally modified, strongly inhibited cathepsin K and cathepsin S weakly, but other cathepsins were not inhibited [9].

Regulatory relationships of Ctss


Other interactions of Ctss


Analytical, diagnostic and therapeutic context of Ctss

  • Northern blot analysis for rat cathepsin S revealed tissue-specific expression distinct from the distribution of cathepsin B and L [1].


  1. Sequence analysis, tissue distribution, and expression of rat cathepsin S. Petanceska, S., Devi, L. J. Biol. Chem. (1992) [Pubmed]
  2. Changes in intragraft gene expression secondary to ischemia reperfusion after cardiac transplantation. Stegall, M.D., Park, W.D., Kim, D.Y., Covarrubias, M., Khair, A., Kremers, W.K. Transplantation (2002) [Pubmed]
  3. The use of adenovirus-mediated gene transfer to develop a rat model for photoreceptor degeneration. Lai, C.M., Shen, W.Y., Constable, I., Rakoczy, P.E. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  4. Comparative study of cathepsins D and S in rat IPE and RPE cells. Sugano, E., Tomita, H., Abe, T., Yamashita, A., Tamai, M. Exp. Eye Res. (2003) [Pubmed]
  5. Microglial functions and proteases. Nakanishi, H. Mol. Neurobiol. (2003) [Pubmed]
  6. Study of the functional share of lysosomal cathepsins by the development of specific inhibitors. Katunuma, N., Matsui, A., Kakegawa, T., Murata, E., Asao, T., Ohba, Y. Adv. Enzyme Regul. (1999) [Pubmed]
  7. Differential distribution of messenger RNAs for cathepsins B, L and S in adult rat brain: an in situ hybridization study. Petanceska, S., Burke, S., Watson, S.J., Devi, L. Neuroscience (1994) [Pubmed]
  8. Specific catalytic activity of cathepsin S in comparison to cathepsins B and L along the rat nephron. Schmid, H., Koop, M., Utermann, S., Lambacher, L., Mayer, P., Schaefer, L. Biol. Chem. (1997) [Pubmed]
  9. Structure-based development of pyridoxal propionate derivatives as specific inhibitors of cathepsin K in vitro and in vivo. Katunuma, N., Matsui, A., Inubushi, T., Murata, E., Kakegawa, H., Ohba, Y., Turk, D., Turk, V., Tada, Y., Asao, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  10. Functional interface between cathepsins and growth factors in the kidney development. Vattimo, M.d.e. .F., Santos, O.F. Renal failure. (2005) [Pubmed]
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