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Gene Review

CLDN2  -  claudin 2

Canis lupus familiaris

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High impact information on CLDN2

  • These data show for the first time that the ERK 1/2 signaling pathway negatively controls claudin-2 expression in mammalian renal epithelial cells and provide evidence for regulation of tight junction paracellular transport by alterations in claudin composition within tight junction complexes [1].
  • Induction of claudin-8 expression was associated with down-regulation of endogenous claudin-2 protein [2].
  • While the amount of claudin-2 protein was reduced similarly to occludin, ZO-1 and ZO-2, claudin-1 was either fully preserved or was even increased in apoptotic cells [3].
  • Overexpression of claudin-2 in the originally tight epithelium with claudin-2 cDNA resulted in a 5.6-fold higher paracellular conductivity and relative ion permeabilities of Na(+) identical with 1, K(+)=1.02, NMDG(+)=0.79, choline(+)=0.71, Cl(-)=0.12, Br(-)=0.10 (vector control, 1:1.04:0.95:0.94:0.85:0.83) [4].
  • DN Rac1 expression also induced selective redistribution of claudins-1 and -2 in addition to JAM-1, whereas DN Cdc42 influenced only claudin-2 and DN RhoA had no effect [5].

Anatomical context of CLDN2

  • Overexpression studies suggest that tight junction leakiness in these two strains of MDCK cells is conferred by expression of the tight junction protein claudin-2 [1].


  1. Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells. Lipschutz, J.H., Li, S., Arisco, A., Balkovetz, D.F. J. Biol. Chem. (2005) [Pubmed]
  2. Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. Yu, A.S., Enck, A.H., Lencer, W.I., Schneeberger, E.E. J. Biol. Chem. (2003) [Pubmed]
  3. The specific fates of tight junction proteins in apoptotic epithelial cells. Bojarski, C., Weiske, J., Schöneberg, T., Schröder, W., Mankertz, J., Schulzke, J.D., Florian, P., Fromm, M., Tauber, R., Huber, O. J. Cell. Sci. (2004) [Pubmed]
  4. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. Amasheh, S., Meiri, N., Gitter, A.H., Schöneberg, T., Mankertz, J., Schulzke, J.D., Fromm, M. J. Cell. Sci. (2002) [Pubmed]
  5. RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Bruewer, M., Hopkins, A.M., Hobert, M.E., Nusrat, A., Madara, J.L. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
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