The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cldn2  -  claudin 2

Mus musculus

Synonyms: AL022813, Claudin-2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Cldn2

  • In glutaraldehyde-fixed samples, claudin-1-induced strands were largely associated with the protoplasmic (P) face as mostly continuous structures, whereas claudin-2-induced strands were discontinuous at the P face with complementary grooves at the extracellular (E) face which were occupied by chains of particles [1].
  • Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA [2].
  • U0126 treatment also induced claudin-2 expression and decreased TER in a high resistance mouse cortical collecting duct cell line (94D) [3].
  • Transfection of constitutively active mitogen-activated protein kinase/extracellular signal-regulated kinase kinase into MDCK strain II cells also inhibited claudin-2 expression and increased TER [3].
  • In order to characterize the contribution of claudin-2 to barrier and permeability properties of the tight junction in detail, we studied two strains of Madin-Darby canine kidney cells (MDCK-C7 and MDCK-C11) with different tight junctional permeabilities [4].

Anatomical context of Cldn2


Associations of Cldn2 with chemical compounds

  • Claudin-2 is selectively expressed in proximal nephron in mouse kidney [7].
  • In Raf-1-transfected cells treated with PD98059 and SB203580, but not LY294002, expression and localization of claudin-2, but not occludin, recovered, together with barrier function, measured as the TER value [8].

Other interactions of Cldn2


Analytical, diagnostic and therapeutic context of Cldn2


  1. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. Furuse, M., Sasaki, H., Fujimoto, K., Tsukita, S. J. Cell Biol. (1998) [Pubmed]
  2. Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Guillemot, L., Citi, S. Mol. Biol. Cell (2006) [Pubmed]
  3. Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells. Lipschutz, J.H., Li, S., Arisco, A., Balkovetz, D.F. J. Biol. Chem. (2005) [Pubmed]
  4. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. Amasheh, S., Meiri, N., Gitter, A.H., Schöneberg, T., Mankertz, J., Schulzke, J.D., Fromm, M. J. Cell. Sci. (2002) [Pubmed]
  5. Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Van Itallie, C.M., Fanning, A.S., Anderson, J.M. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  6. IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways. Yamamoto, T., Kojima, T., Murata, M., Takano, K., Go, M., Chiba, H., Sawada, N. Exp. Cell Res. (2004) [Pubmed]
  7. Claudin-2 is selectively expressed in proximal nephron in mouse kidney. Enck, A.H., Berger, U.V., Yu, A.S. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
  8. Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line. Lan, M., Kojima, T., Osanai, M., Chiba, H., Sawada, N. Carcinogenesis (2004) [Pubmed]
  9. Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse. Wolburg, H., Wolburg-Buchholz, K., Liebner, S., Engelhardt, B. Neurosci. Lett. (2001) [Pubmed]
  10. Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. Acharya, P., Beckel, J., Ruiz, W.G., Wang, E., Rojas, R., Birder, L., Apodaca, G. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
WikiGenes - Universities