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Gene Review

Cldn1  -  claudin 1

Mus musculus

Synonyms: AI596271, Claudin-1
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Disease relevance of Cldn1


High impact information on Cldn1


Biological context of Cldn1


Anatomical context of Cldn1


Associations of Cldn1 with chemical compounds


Physical interactions of Cldn1

  • Transfection experiments with various promoter constructs as well as electrophoretic mobility assays revealed that Snail binds directly to the E-boxes of the promoters of claudin/occludin genes, resulting in complete repression of their promoter activity [20].
  • So far among these candidate proteins, dynein, claudin and silencer of death domains co-immunoprecipitated with the CSF-1R, suggesting association [21].

Co-localisations of Cldn1

  • The myc-tagged claudin-1 precisely colocalized with both occludin and ZO-1 at cell-cell contact sites, indicating that exogenous claudin-1 was properly targeted to the TJs [22].

Other interactions of Cldn1


Analytical, diagnostic and therapeutic context of Cldn1


  1. Expression and targeting of the tight junction protein CLDN1 in CLDN1-negative human breast tumor cells. Hoevel, T., Macek, R., Mundigl, O., Swisshelm, K., Kubbies, M. J. Cell. Physiol. (2002) [Pubmed]
  2. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. Morita, K., Sasaki, H., Furuse, M., Tsukita, S. J. Cell Biol. (1999) [Pubmed]
  3. Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1. Oku, N., Sasabe, E., Ueta, E., Yamamoto, T., Osaki, T. Cancer Res. (2006) [Pubmed]
  4. Differential expression of claudin family proteins in mouse ovarian serous papillary epithelial adenoma in aging FSH receptor-deficient mutants. Aravindakshan, J., Chen, X., Sairam, M.R. Neoplasia (2006) [Pubmed]
  5. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. Fujita, K., Katahira, J., Horiguchi, Y., Sonoda, N., Furuse, M., Tsukita, S. FEBS Lett. (2000) [Pubmed]
  6. Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Gudjonsson, T., Villadsen, R., Nielsen, H.L., Rønnov-Jessen, L., Bissell, M.J., Petersen, O.W. Genes Dev. (2002) [Pubmed]
  7. Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. Miyamoto, T., Morita, K., Takemoto, D., Takeuchi, K., Kitano, Y., Miyakawa, T., Nakayama, K., Okamura, Y., Sasaki, H., Miyachi, Y., Furuse, M., Tsukita, S. J. Cell Biol. (2005) [Pubmed]
  8. Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. Itoh, M., Sasaki, H., Furuse, M., Ozaki, H., Kita, T., Tsukita, S. J. Cell Biol. (2001) [Pubmed]
  9. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y., Tsukita, S. J. Cell Biol. (1999) [Pubmed]
  10. Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease. Lee, N.P., Tong, M.K., Leung, P.P., Chan, V.W., Leung, S., Tam, P.C., Chan, K.W., Lee, K.F., Yeung, W.S., Luk, J.M. FEBS Lett. (2006) [Pubmed]
  11. claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Niimi, T., Nagashima, K., Ward, J.M., Minoo, P., Zimonjic, D.B., Popescu, N.C., Kimura, S. Mol. Cell. Biol. (2001) [Pubmed]
  12. Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Kubota, K., Furuse, M., Sasaki, H., Sonoda, N., Fujita, K., Nagafuchi, A., Tsukita, S. Curr. Biol. (1999) [Pubmed]
  13. Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Fujibe, M., Chiba, H., Kojima, T., Soma, T., Wada, T., Yamashita, T., Sawada, N. Exp. Cell Res. (2004) [Pubmed]
  14. Expression of TM4SF10, a Claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation. Bruggeman, L.A., Martinka, S., Simske, J.S. Dev. Dyn. (2007) [Pubmed]
  15. Dynamic behavior of paired claudin strands within apposing plasma membranes. Sasaki, H., Matsui, C., Furuse, K., Mimori-Kiyosue, Y., Furuse, M., Tsukita, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  16. Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments. Kiuchi-Saishin, Y., Gotoh, S., Furuse, M., Takasuga, A., Tano, Y., Tsukita, S. J. Am. Soc. Nephrol. (2002) [Pubmed]
  17. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. Furuse, M., Sasaki, H., Fujimoto, K., Tsukita, S. J. Cell Biol. (1998) [Pubmed]
  18. Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line. Kojima, T., Spray, D.C., Kokai, Y., Chiba, H., Mochizuki, Y., Sawada, N. Exp. Cell Res. (2002) [Pubmed]
  19. Expression of claudin-1 in mouse testis. Gye, M.C. Arch. Androl. (2003) [Pubmed]
  20. Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. Ikenouchi, J., Matsuda, M., Furuse, M., Tsukita, S. J. Cell. Sci. (2003) [Pubmed]
  21. A proteomics strategy for the enrichment of receptor-associated complexes. Cross, M., Nguyen, T., Bogdanoska, V., Reynolds, E., Hamilton, J.A. Proteomics (2005) [Pubmed]
  22. Claudin-1 contributes to the epithelial barrier function in MDCK cells. Inai, T., Kobayashi, J., Shibata, Y. Eur. J. Cell Biol. (1999) [Pubmed]
  23. Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cells. McCarthy, K.M., Francis, S.A., McCormack, J.M., Lai, J., Rogers, R.A., Skare, I.B., Lynch, R.D., Schneeberger, E.E. J. Cell. Sci. (2000) [Pubmed]
  24. Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouse. Wolburg, H., Wolburg-Buchholz, K., Liebner, S., Engelhardt, B. Neurosci. Lett. (2001) [Pubmed]
  25. Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: preferential localization of claudin-4 at the apex of the dome region. Tamagawa, H., Takahashi, I., Furuse, M., Yoshitake-Kitano, Y., Tsukita, S., Ito, T., Matsuda, H., Kiyono, H. Lab. Invest. (2003) [Pubmed]
  26. Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. Kitajiri, S.I., Furuse, M., Morita, K., Saishin-Kiuchi, Y., Kido, H., Ito, J., Tsukita, S. Hear. Res. (2004) [Pubmed]
  27. Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Nico, B., Frigeri, A., Nicchia, G.P., Corsi, P., Ribatti, D., Quondamatteo, F., Herken, R., Girolamo, F., Marzullo, A., Svelto, M., Roncali, L. Glia (2003) [Pubmed]
  28. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. Amasheh, S., Meiri, N., Gitter, A.H., Schöneberg, T., Mankertz, J., Schulzke, J.D., Fromm, M. J. Cell. Sci. (2002) [Pubmed]
  29. Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study. Shi, L.Z., Zheng, W. Brain Res. (2005) [Pubmed]
  30. Changes in the expression of claudins and transepithelial electrical resistance of mouse Sertoli cells by Leydig cell coculture. Gye, M.C. Int. J. Androl. (2003) [Pubmed]
  31. Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouse. Blanchard, A.A., Watson, P.H., Shiu, R.P., Leygue, E., Nistor, A., Wong, P., Myal, Y. DNA Cell Biol. (2006) [Pubmed]
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