The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

POU1F1  -  POU class 1 homeobox 1

Canis lupus familiaris

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of POU1F1

  • Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism [1].
  • Here we show that an immunodeficiency-inducing, T cell-tropic feline leukemia virus (FeLV) has evolved such that it cannot infect cells unless both a classic multiple membrane-spanning receptor molecule (Pit1) and a second coreceptor or entry factor are present [2].

High impact information on POU1F1

  • The full-length canine Pit-1 cDNA contained an open reading frame encoding 291 amino acids, 92 bp of 5'-untranslated region, and 1959 bp of 3'-untranslated region [1].
  • The deduced amino acid sequence was highly homologous with Pit-1 of other mammalian species [1].
  • Using a Pit-1 BAC clone as probe, the Pit-1 gene was mapped by FISH to canine Chromosome (Chr) 31 [1].
  • In addition, linkage analysis of polymorphic DNA markers flanking the Pit-1 gene, 41K19 and 52L05, revealed no co-segregation between the Pit-1 locus and the CPHD phenotype [1].
  • Pituitary GH gene expression is highly dependent upon the transcription factor Pit-1 [3].

Biological context of POU1F1


  1. Cloning of the canine gene encoding transcription factor Pit-1 and its exclusion as candidate gene in a canine model of pituitary dwarfism. Lantinga-van Leeuwen, I.S., Mol, J.A., Kooistra, H.S., Rijnberk, A., Breen, M., Renier, C., van Oost, B.A. Mamm. Genome (2000) [Pubmed]
  2. Identification of a cellular cofactor required for infection by feline leukemia virus. Anderson, M.M., Lauring, A.S., Burns, C.C., Overbaugh, J. Science (2000) [Pubmed]
  3. Canine mammary growth hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1. Lantinga-van Leeuwen, I.S., Oudshoorn, M., Mol, J.A. Mol. Cell. Endocrinol. (1999) [Pubmed]
WikiGenes - Universities