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Gene Review

POU1F1  -  POU class 1 homeobox 1

Gallus gallus

Synonyms: GHF-1, PIT-1, PIT1, Pit-1*
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Disease relevance of POU1F1

  • The results revealed a positive relationship between genotype A/A and body weight at 8 weeks of age, indicating that the SNP in PIT1 gene is a potential molecular marker for early growth rate in chicken [1].

High impact information on POU1F1


Biological context of POU1F1


Anatomical context of POU1F1

  • Applying this method, the effect of TRH injections on Pit-1 mRNA expression was determined in the pituitary of chick embryos and growing chicks [7].
  • The expression of the thyrotropin (TSH) gene in the pituitary gland is thought to be dependent upon the pituitary-specific transcription factor, Pit-1 [8].
  • In some of these tissues (particularly in brain and spinal cord ependymal cells, cells in the otic vesicle and in liver hepatocytes), the distribution of TSH immunoreactivity was overlapped by the distribution of immunoreactive Pit-1, suggesting Pit-1 involvement in TSH expression in these sites [8].
  • However, in other tissues (e.g., the trigeminal nerve in the head and the marginal mantle layer of the spinal cord), Pit-1 immunoreactivity was intense but TSH immunoreactivity was marginal [8].
  • Conversely, other tissues (e.g., cells in the skin, blood vessels, limb bud, bronchus, proventriculus, and cardiopleural cavities) had intense TSH staining but little, if any, Pit-1 immunoreactivity [8].

Associations of POU1F1 with chemical compounds

  • This nucleotide transversion results in an alteration of codon 299 from AAC to ATC, which leads to a change from asparagine (Asn) to isoleucine (Ile) in the POU domain of POU1F1 [1].
  • Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary [7].
  • Pit-1 immunoreaction products were colocalized in the glandular cells immunopositive for growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone or prolactin [9].

Regulatory relationships of POU1F1


Analytical, diagnostic and therapeutic context of POU1F1

  • In the present study, we successfully developed a competitive RT-PCR for the detection of Pit-1 expression in the chicken pituitary, that was sensitive enough to detect picogram levels of Pit-1 mRNA [7].
  • Northern blot analysis revealed the pituitary-specific expressions of these Pit-1 mRNAs, and the Pit-1alpha mRNA expressions were two to three times higher than those for Pit-1gamma in both cephalic and caudal lobes of the pituitary [11].


  1. A new single nucleotide polymorphism in the chicken pituitary-specific transcription factor (POU1F1) gene associated with growth rate. Jiang, R., Li, J., Qu, L., Li, H., Yang, N. Anim. Genet. (2004) [Pubmed]
  2. Role of the progressive ankylosis gene (ank) in cartilage mineralization. Wang, W., Xu, J., Du, B., Kirsch, T. Mol. Cell. Biol. (2005) [Pubmed]
  3. Glucocorticoid induction of lactotrophs and prolactin gene expression in chicken embryonic pituitary cells: a delayed response relative to stimulated growth hormone production. Fu, X., Porter, T.E. Endocrinology (2004) [Pubmed]
  4. Molecular cloning and characterization of the yellowtail GH gene and its promoter: a consensus sequence for teleost and avian Pit-1/GHF-1 binding sites. Ohkubo, T., Araki, M., Tanaka, M., Sudo, S., Nakashima, K. J. Mol. Endocrinol. (1996) [Pubmed]
  5. Complementary DNA cloning and ontogenic expression of pituitary-specific transcription factor of chickens (Gallus domesticus) from the pituitary gland. Van As, P., Buys, N., Onagbesan, O.M., Decuypere, E. Gen. Comp. Endocrinol. (2000) [Pubmed]
  6. Structure of the chicken growth hormone-encoding gene and its promoter region. Tanaka, M., Hosokawa, Y., Watahiki, M., Nakashima, K. Gene (1992) [Pubmed]
  7. Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary. Van As, P., Careghi, C., Bruggeman, V., Onagbesan, O.M., Van der Geyten, S., Darras, V.M., Decuypere, E. Acta Vet. Hung. (2004) [Pubmed]
  8. Extrapituitary TSH in early chick embryos: Pit-1 dependence? Murphy, A.E., Harvey, S. J. Mol. Neurosci. (2002) [Pubmed]
  9. Immunocytochemical identification of Pit-1 containing cells in the anterior pituitary of hens. Chowdhury, V.S., Yoshimura, Y. J. Reprod. Dev. (2003) [Pubmed]
  10. Development of thyroid-stimulating hormone beta subunit-producing cells in the chicken embryonic pituitary gland. Nakamura, K., Iwasawa, A., Kidokoro, H., Komoda, M., Zheng, J., Maseki, Y., Inoue, K., Sakai, T. Cells Tissues Organs (Print) (2004) [Pubmed]
  11. cDNA cloning and developmental alterations in gene expression of the two Pit-1/GHF-1 transcription factors in the chicken pituitary. Tanaka, M., Yamamoto, I., Ohkubo, T., Wakita, M., Hoshino, S., Nakashima, K. Gen. Comp. Endocrinol. (1999) [Pubmed]
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