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Gene Review

HAPLN4  -  hyaluronan and proteoglycan link protein 4

Homo sapiens

Synonyms: BRAL2, Brain link protein 2, Hyaluronan and proteoglycan link protein 4, KIAA1926
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High impact information on HAPLN4

  • Two of the four link protein genes (HAPLN2 and HAPLN4) were restricted in expression to the brain/central nervous system, while one of the four genes (HAPLN3) was widely expressed [1].
  • The substantial immunoreactivity of Bral2 is found in several nuclei throughout the midbrain and hindbrain in a perineuronal net pattern [2].
  • In situ hybridization revealed that Bral2 is synthesized by these neurons themselves, especially by the GABAergic neurons in the cerebellar cortex [2].
  • Our results suggest that Bral2 is involved in the formation of extracellular matrix contributing to perineuronal nets and facilitate the understanding of a functional role of these extracellular matrices [2].

Analytical, diagnostic and therapeutic context of HAPLN4

  • We report here the molecular cloning and expression analysis of a novel member of LPs: Bral2, predominantly expressed in brain [2].


  1. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. Spicer, A.P., Joo, A., Bowling, R.A. J. Biol. Chem. (2003) [Pubmed]
  2. Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets. Bekku, Y., Su, W.D., Hirakawa, S., Fässler, R., Ohtsuka, A., Kang, J.S., Sanders, J., Murakami, T., Ninomiya, Y., Oohashi, T. Mol. Cell. Neurosci. (2003) [Pubmed]
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