Disease relevance of CD23

• Enhanced expression of CD23 on gut epithelial cells was found in inflammatory bowel diseases, in children with food intolerance to cows' milk proteins and in a young infant with severe autoimmune enteropathy [1].

High impact information on CD23

• These data show that CD23 is constitutively expressed by intestinal epithelial cells and that its expression is enhanced in enteropathies [1].
• The equine CD23 sequence encodes a complete and continuous open reading frame of 327 amino acids, while the shorter cattle fragment encodes 209 amino acids corresponding to nucleotides 325-1098 of the equine CD23 transcript [2].
• Using PCR and cDNA library screening, a 2.7kb cDNA encoding equine CD23 and a 627bp PCR fragment of cattle CD23 were sequenced and characterized [2].
• In addition, we found that spleen cells from naive low- and high-responder mice captured IgE/antigen complexes exclusively on B cells, and that the binding was completely inhibited by monoclonal antibodies (MoAbs) against the low-affinity receptor for IgE (FcepsilonRII or CD23) [3].

Analytical, diagnostic and therapeutic context of CD23

• Molecular cloning and sequencing of the low-affinity IgE receptor (CD23) for horse and cattle [2].
• Western blot analysis of anti-CD23 mAb reactivity with gut epithelial cell extracts showed the presence of a non-reducible 42,000-45,000 M(r) polypeptide compatible with the membrane form of the intact CD23 molecule [1].

References