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Gene Review:

djl - don juan like

Drosophila melanogaster

Synonyms: CG1984, Dmel\CG1984, Don Juan-like, dj like, dj-like

Hempel, L.U. et al.

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Disease relevance of djl

Premature expression of Myc-Don Juan Like does not impair spermatogenesis where-as Don Juan-eGFP when prematurely expressed causes male sterility as spermatids fail to individualize [1].

High impact information on djl

In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF(II)80 cannonball while translational repression is achieved by distinct elements [1].
Our in vivo analysis revealed that don juan and don juan like are transcriptionally and translationally controlled by distinct short cis regulatory regions [1].
Prematurely expressed Don Juan-eGFP and Myc-Don Juan Like localize to the cytoplasm of spermatocytes and in mitochondrial derivatives from the nebenkern stage onward suggesting that both proteins associate with the mitochondria along the flagella in elongated spermatids [1].

References

In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF(II)80 cannonball while translational repression is achieved by distinct elements. Hempel, L.U., Rathke, C., Raja, S.J., Renkawitz-Pohl, R. Dev. Dyn. (2006) [Pubmed]

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