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Gene Review

Mcm2  -  Minichromosome maintenance 2

Drosophila melanogaster

Synonyms: CG7538, DNA replication licensing factor Mcm2, DmMCM2, DmMcm2, DmeMCM2, ...
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High impact information on Mcm2

  • These results suggest that DmMCM2 plays a role in the regulation of DNA replication analogous to that of its yeast counterpart [1].
  • DmMCM2 is expressed in the embryo in a pattern corresponding to that of S-phase cells [1].
  • We demonstrate that cyclin E can drive chromosome association of DmMCM2 and that DNA synthesis erases this association [2].


  1. Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. Treisman, J.E., Follette, P.J., O'Farrell, P.H., Rubin, G.M. Genes Dev. (1995) [Pubmed]
  2. Chromosome association of minichromosome maintenance proteins in Drosophila endoreplication cycles. Su, T.T., O'Farrell, P.H. J. Cell Biol. (1998) [Pubmed]
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