High impact information on GDF9

• OSFs and GDF9 both potently enhanced IGF1-stimulated proliferation, and inhibited FSH-stimulated progesterone secretion [1].
• Denuded oocytes, GDF9, and DHT independently inhibited FSH-stimulated progesterone secretion, and androgen, together with DO or GDF9, caused the most potent steroidogenic inhibition [1].
• Antiandrogen (hydroxyflutamide) treatment, which is used to block androgen receptor activity, opposed the interaction between androgen and GDF9 [1].
• In conclusion, androgens stimulate porcine MGC proliferation in vitro by potentiating the growth-promoting effects of oocytes or GDF9, via a mechanism that involves the AR [1].
• Expression of growth differentiation factor 9 messenger RNA in porcine growing and preovulatory ovarian follicles [2].

Biological context of GDF9

• Partial molecular characterization and mapping of the GDF9 gene to porcine chromosome 2 [3].

Associations of GDF9 with chemical compounds

• Alone, DHT had little effect on DNA synthesis, but significantly enhanced the mitogenic effects of OSFs or GDF9 in the presence of IGF1 [1].

References