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Gene Review:

PIM3 - Pim-3 proto-oncogene, serine/threonine kinase

Homo sapiens

Synonyms: Serine/threonine-protein kinase pim-3

Deneen, B. et al., Gupta, J. et al., Mikkers, H. et al., Jelić-Ivanović, Z. et al.

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Disease relevance of PIM3

Low frequency of PIM3 gene in patients with monoclonal gammopathies [1].
Association of the PIM3 allele of the alpha-1-antitrypsin gene with chronic obstructive pulmonary disease [2].

High impact information on PIM3

The Pim family of proto-oncogenes encodes a distinct class of serine/threonine kinases consisting of PIM1, PIM2, and PIM3 [3].
PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins [4].
PIM3 was found to be expressed in a panel of human Ewing's family tumor cell lines [4].
However, the PIM3 allele of the alpha1AT gene was found to be associated with COPD [2].

Regulatory relationships of PIM3

The proto-oncogene coding for serine/threonine kinase PIM3 was found to one of several genes encoding signal transduction proteins that were up-regulated by EWS/ETS fusions [4].

References

Low frequency of PIM3 gene in patients with monoclonal gammopathies. Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Stanković, B., Topić, A., Spasić, S. Hum. Hered. (1996) [Pubmed]
Association of the PIM3 allele of the alpha-1-antitrypsin gene with chronic obstructive pulmonary disease. Gupta, J., Bhadoria, D.P., Lal, M.K., Kukreti, R., Chattopadhaya, D., Gupta, V.K., Dabur, R., Yadav, V., Chhillar, A.K., Sharma, G.L. Clin. Biochem. (2005) [Pubmed]
Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mikkers, H., Nawijn, M., Allen, J., Brouwers, C., Verhoeven, E., Jonkers, J., Berns, A. Mol. Cell. Biol. (2004) [Pubmed]
PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Deneen, B., Welford, S.M., Ho, T., Hernandez, F., Kurland, I., Denny, C.T. Mol. Cell. Biol. (2003) [Pubmed]

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PIM3	Bos taurus
PIM3	Gallus gallus
PIM3	Macaca mulatta
Pim3	Mus musculus
Pim3	Rattus norvegicus
LOC100497723	Xenopus (Silurana) tropicalis

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