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Gene Review:

HBAA - hemoglobin, alpha 1

Gallus gallus

Iarovaia, O. et al., Bronstein, I.B. et al., Eguchi, Y. et al., Lewis, W. et al., Eguchi, Y. et al.

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High impact information on HBA1

When subcloned DNAs containing one or the other gene are stably transfected into QT6 quail fibroblasts, the alpha A-globin gene is expressed at measurable RNA levels, but the alpha D gene is not [1].
Using hybridization in situ with a ribo-probe recognizing transcripts of the chicken alpha A globin gene, we show here that in proliferating AEV-transformed erythroblasts this gene is strongly transcribed, but the corresponding transcripts are retained in the nuclei [2].
Mapping of topo I cleavage sites of the cloned chicken alpha A-globin and human c-Ha-ras genes was carried out [3].
Specific cleavage of chicken alpha A-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I [3].
The amino acid sequence of turkey alpha A-globin differs by only one residue from chicken alpha A-globin [4].

Biological context of HBA1

The cDNA clones coding for the alpha A globin were isolated from the quail reticulocyte cDNA library, mapped by restriction enzyme digestion, and the nucleotide sequence was determined completely [5].

References

Adult chicken alpha-globin gene expression in transfected QT6 quail cells: evidence for a negative regulatory element in the alpha D gene region. Lewis, W., Lee, J.D., Dodgson, J.B. Nucleic Acids Res. (1991) [Pubmed]
In chicken leukemia cells globin genes are fully transcribed but their rnas are retained in the perinucleolar area. Iarovaia, O., Razin, S.V., Linares-Cruz, G., Sjakste, N., Scherrer, K. Exp. Cell Res. (2001) [Pubmed]
Specific cleavage of chicken alpha A-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I. Bronstein, I.B., Gromova, I.I., Razin, S.V. Mol. Cell. Biochem. (1991) [Pubmed]
Amino acid sequence of alpha- and beta-polypeptide chains of turkey (Meleagris gallopavo) hemoglobin. Eguchi, Y., Ikehara, T., Kayo, S., Eguchi, T., Takei, H. Biol. Chem. Hoppe-Seyler (1995) [Pubmed]
Protein structure and cDNA nucleotide sequence of the Japanese quail alpha A globin. Eguchi, Y., Takei, H., Oshiro, M., Toda, T., Nakashima, Y. Biol. Chem. Hoppe-Seyler (1991) [Pubmed]

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HBA	Bos taurus
HBA1	Bos taurus
LOC100855540	Canis lupus familiaris
LOC100855558	Canis lupus familiaris
LOC100858011	Gallus gallus
HBA1	Homo sapiens
HBA2	Homo sapiens
HBA2	Macaca mulatta
HBA2	Macaca mulatta
Hba-a2	Mus musculus
Hba-a1	Mus musculus
LOC287167	Rattus norvegicus
hba1	Xenopus (Silurana) tropicalis

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