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Gene Review

HBA2  -  hemoglobin, alpha 2

Homo sapiens

Synonyms: HBA-T2, HBH
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Disease relevance of HBA2

  • In addition, male clusters differed significantly for percent ever having had pneumonia, priapism, or dactylitis, and females differed significantly for height and weight. %Hb F and its inverse relationship with %HBA2 was more highly associated with the measures of severity than the degree of anemia or MCV [1].
  • One hundred ninety-seven children with sickle cell anemia were followed for 4 years at the Wayne State Comprehensive Sickle Cell Center to evaluate the stability of the hematological variables (Hb, Hct, RBC count, MCV, %HbF and %HBA2) over time [2].
  • Nineteen patients had positive serological tests for syphilis (TPHA) and two men, both homosexuals, had positive hepatitis (HBA2) serology [3].

High impact information on HBA2

  • The HBA1 (alpha1-globin) and HBA2 (alpha2-globin) genes were individually amplified and sequenced [4].

Biological context of HBA2


Other interactions of HBA2

  • The HBA2 alleles c.1A>G, c.79G>A, and c.281T>G, and the HBA1 allele c.475C>A were new [5].


  1. Heterogeneity of sickle-cell anemia based on a profile of hematological variables. Odenheimer, D.J., Whitten, C.F., Rucknagel, D.L., Sarnaik, S.A., Sing, C.F. Am. J. Hum. Genet. (1983) [Pubmed]
  2. Stability over time of hematological variables in 197 children with sickle cell anemia. Odenheimer, D.J., Whitten, C.F., Rucknagel, D.A., Sarnaik, S.A., Sing, C.F. Am. J. Med. Genet. (1984) [Pubmed]
  3. Sexuality and sexually transmitted diseases in older men attending the Genito-Urinary Clinic in Birmingham. Opaneye, A.A. Journal of the Royal Society of Health. (1991) [Pubmed]
  4. Determining the cause of patchwork HBA1 and HBA2 genes: recurrent gene conversion or crossing over fixation events. Law, H.Y., Luo, H.Y., Wang, W., Ho, J.F., Najmabadi, H., Ng, I.S., Steinberg, M.H., Chui, D.H., Chong, S.S. Haematologica (2006) [Pubmed]
  5. Sequence variations of the alpha-globin genes: scanning of high CG content genes with DHPLC and DG-DGGE. Lacerra, G., Fiorito, M., Musollino, G., Di Noce, F., Esposito, M., Nigro, V., Gaudiano, C., Carestia, C. Hum. Mutat. (2004) [Pubmed]
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