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Gene Review

Hba-a2  -  hemoglobin alpha, adult chain 2

Mus musculus

Synonyms: alpha 2 globin
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  • Analysis of human embryonic and early fetal erythroid RNA samples confirmed this possibility; levels of mRNA encoded by the two alpha-globin loci are equal in the embryo and subsequently shift to dominant expression of the alpha 2-globin locus at week 8 in utero [6].


  1. Erythroid cell-specific determinants of alpha-globin mRNA stability. Weiss, I.M., Liebhaber, S.A. Mol. Cell. Biol. (1994) [Pubmed]
  2. High expression of human beta S- and alpha-globins in transgenic mice: erythrocyte abnormalities, organ damage, and the effect of hypoxia. Fabry, M.E., Costantini, F., Pachnis, A., Suzuka, S.M., Bank, N., Aynedjian, H.S., Factor, S.M., Nagel, R.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Targeted inactivation of the major positive regulatory element (HS-40) of the human alpha-globin gene locus. Bernet, A., Sabatier, S., Picketts, D.J., Ouazana, R., Morlé, F., Higgs, D.R., Godet, J. Blood (1995) [Pubmed]
  4. Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region. Weiss, I.M., Liebhaber, S.A. Mol. Cell. Biol. (1995) [Pubmed]
  5. Molecular basis for alpha-thalassemia associated with the structural mutant hemoglobin Suan-Dok (alpha 2 109leu----arg). Weiss, I., Cash, F.E., Coleman, M.B., Pressley, A., Adams, J.G., Sanguansermsri, T., Liebhaber, S.A., Steinberg, M.H. Blood (1990) [Pubmed]
  6. Developmental switch in the relative expression of the alpha 1- and alpha 2-globin genes in humans and in transgenic mice. Albitar, M., Cash, F.E., Peschle, C., Liebhaber, S.A. Blood (1992) [Pubmed]
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