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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AQP1  -  aquaporin 1 (Colton blood group)

Gallus gallus

 
 
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High impact information on AQP1

  • Characterization of the antibodies showed that they recognized their corresponding fusion proteins as well as native AQP1 in erythrocytes and recombinant AQP1 expressed in COS7 cells [1].
  • Aquaporin-1 (AQP1) is a member of a family of integral membrane proteins, the aquaporins, which function as molecular channels for the movement of water across the plasma membrane [1].
  • Immunohistochemical analysis of AQP1 distribution in cryosections of nasal gland indicated that AQP1 is mainly expressed in endothelial cells of the capillaries, but definitely not in the secretory or ductal cells of the gland [2].
 

Analytical, diagnostic and therapeutic context of AQP1

  • Western blot analysis of AQP1 and AQP5 expression in the glands revealed that protein abundance decreased in a similar fashion [2].

References

  1. Characterization of the transmembrane orientation of aquaporin-1 using antibodies to recombinant fusion proteins. Stamer, W.D., Snyder, R.W., Regan, J.W. Biochemistry (1996) [Pubmed]
  2. Downregulation of aquaporins 1 and 5 in nasal gland by osmotic stress in ducklings, Anas platyrhynchos: implications for the production of hypertonic fluid. M??ller, C., Sendler, M., Hildebrandt, J.P. J. Exp. Biol. (2006) [Pubmed]
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