The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Aqp1  -  aquaporin 1

Mus musculus

Synonyms: AQP-1, Aquaporin-1, Aquaporin-CHIP, CHIP28, DER2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Aqp1


Psychiatry related information on Aqp1

  • Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice [5].
  • The expression of AQP2 and UT-A1, but not UT-A2 mRNAs, was increased to the same level as that of the wild type mice in the water deprivation state, indicating that the vasopressin regulatory mechanism was not affected by OREBPdn [6].

High impact information on Aqp1

  • The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of how water specifically crosses biological membranes [7].
  • P(f) was reduced 10-fold by AQP5 deletion and was further reduced by 2- to 3-fold in AQP1/AQP5 double-knockout mice [8].
  • We previously studied the role of AQP1 and AQP4 in lung fluid transport using knockout mice [8].
  • Deletion of AQP1 in mice results in diminished urinary concentrating ability, possibly related to reduced NaCl- and urea gradient-driven water transport across the outer medullary descending vasa recta (OMDVR) [9].
  • Interestingly, urea was also able to drive water movement across the AQP1-independent pathway [9].

Chemical compound and disease context of Aqp1


Biological context of Aqp1

  • This article describes new renal physiologic insights revealed by phenotype analysis of aquaporin-knockout mice and the prospects for further basic and clinical developments [13].
  • Aquaporin (AQP) water channels provide a major pathway for osmotically driven water movement across epithelial and microvascular barriers in the lung [3].
  • Here, we have investigated the long-term consequences of deletion of the AQP1 gene product by profiling abundance changes in transporters expressed in the inner medullas of AQP1 (-/-) mice vs. heterozygotes [AQP1 (+/-)], which have a normal concentrating capacity [14].
  • Urea and urine concentrating ability in mice lacking AQP1 and AQP3 [15].
  • The up-regulation of AQP1 expression and/or function in corneal endothelium may reduce corneal swelling and opacification following injury [16].

Anatomical context of Aqp1

  • These results indicate that osmotically driven water transport across microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that the microvascular endothelium is a significant barrier for airspace-capillary osmotic water transport [1].
  • Both approaches indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in response to a 5- to 10-cm H2O increase in pulmonary artery pressure for five minutes [1].
  • Here AQP1/AQP3 double knockout mice were generated and analyzed to investigate the functional role of AQP3 in erythrocytes and kidneys [2].
  • Using mice deficient in selected aquaporins as controls, we localized AQP1 in fibrocytes in the spiral ligament and AQP4 in supporting epithelial cells (Hensen's, Claudius, and inner sulcus cells) in the organ of Corti [17].
  • Evidence against functionally significant aquaporin expression in mitochondria [18].

Associations of Aqp1 with chemical compounds


Regulatory relationships of Aqp1


Other interactions of Aqp1


Analytical, diagnostic and therapeutic context of Aqp1

  • At 5 cm H(2)O outflow pressure, the filtration coefficient was 4.7 cm(3) s(-1) mOsm(-1) and reduced 1.4-fold by AQP1 deletion [27].
  • Mice lacking AQP1 have reduced IOP and impaired corneal transparency after swelling, and mice lacking AQP4 have reduced light-evoked potentials by electroretinography [28].
  • By in situ hybridization and immunohistochemical techniques, subtle differences between transcript and protein expression patterns were noted for both AQP1 and 5 [25].
  • Therefore, AQP1 provides a major route for osmotically driven water transport across the peritoneal barrier in peritoneal dialysis [29].
  • Immunofluorescence showed AQP1 protein in capillary endothelia and mesangium near the peritoneal surface and AQP4 in adherent muscle plasmalemma [29].


  1. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. Bai, C., Fukuda, N., Song, Y., Ma, T., Matthay, M.A., Verkman, A.S. J. Clin. Invest. (1999) [Pubmed]
  2. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. Yang, B., Ma, T., Verkman, A.S. J. Biol. Chem. (2001) [Pubmed]
  3. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. Song, Y., Fukuda, N., Bai, C., Ma, T., Matthay, M.A., Verkman, A.S. J. Physiol. (Lond.) (2000) [Pubmed]
  4. Roles of aquaporins in kidney revealed by transgenic mice. Verkman, A.S. Semin. Nephrol. (2006) [Pubmed]
  5. Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice. Rodr??guez, A., P??rez-Gracia, E., Espinosa, J.C., Pumarola, M., Torres, J.M., Ferrer, I. Acta Neuropathol. (2006) [Pubmed]
  6. Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism. Lam, A.K., Ko, B.C., Tam, S., Morris, R., Yang, J.Y., Chung, S.K., Chung, S.S. J. Biol. Chem. (2004) [Pubmed]
  7. Aquaporins in the kidney: from molecules to medicine. Nielsen, S., Frøkiaer, J., Marples, D., Kwon, T.H., Agre, P., Knepper, M.A. Physiol. Rev. (2002) [Pubmed]
  8. Lung fluid transport in aquaporin-5 knockout mice. Ma, T., Fukuda, N., Song, Y., Matthay, M.A., Verkman, A.S. J. Clin. Invest. (2000) [Pubmed]
  9. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. Pallone, T.L., Edwards, A., Ma, T., Silldorff, E.P., Verkman, A.S. J. Clin. Invest. (2000) [Pubmed]
  10. Glycerol transport: an additional target for obesity therapy? Wintour, E.M., Henry, B.A. Trends Endocrinol. Metab. (2006) [Pubmed]
  11. Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma. Xiang, Y., Ma, B., Li, T., Yu, H.M., Li, X.J. Acta Pharmacol. Sin. (2002) [Pubmed]
  12. The role of aquaporin-1 (AQP1) expression in a murine model of lipopolysaccharide-induced acute lung injury. Su, X., Song, Y., Jiang, J., Bai, C. Respiratory physiology & neurobiology. (2004) [Pubmed]
  13. Lessons on renal physiology from transgenic mice lacking aquaporin water channels. Verkman, A.S. J. Am. Soc. Nephrol. (1999) [Pubmed]
  14. Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice. Morris, R.G., Uchida, S., Brooks, H., Knepper, M.A., Chou, C.L. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  15. Urea and urine concentrating ability in mice lacking AQP1 and AQP3. Zhao, D., Bankir, L., Qian, L., Yang, D., Yang, B. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  16. Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. Thiagarajah, J.R., Verkman, A.S. J. Biol. Chem. (2002) [Pubmed]
  17. Impaired hearing in mice lacking aquaporin-4 water channels. Li, J., Verkman, A.S. J. Biol. Chem. (2001) [Pubmed]
  18. Evidence against functionally significant aquaporin expression in mitochondria. Yang, B., Zhao, D., Verkman, A.S. J. Biol. Chem. (2006) [Pubmed]
  19. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Moore, M., Ma, T., Yang, B., Verkman, A.S. Exp. Eye Res. (2000) [Pubmed]
  20. Aquaporin water channel genes are differentially expressed and regulated by ovarian steroids during the periimplantation period in the mouse. Richard, C., Gao, J., Brown, N., Reese, J. Endocrinology (2003) [Pubmed]
  21. Aquaporin-5 dependent fluid secretion in airway submucosal glands. Song, Y., Verkman, A.S. J. Biol. Chem. (2001) [Pubmed]
  22. Aquaporin 1 is important for maintaining secretory granule biogenesis in endocrine cells. Arnaoutova, I., Cawley, N.X., Patel, N., Kim, T., Rathod, T., Loh, Y.P. Mol. Endocrinol. (2008) [Pubmed]
  23. Modulation of hypertonicity-induced aquaporin-1 by sodium chloride, urea, betaine, and heat shock in murine renal medullary cells. Umenishi, F., Yoshihara, S., Narikiyo, T., Schrier, R.W. J. Am. Soc. Nephrol. (2005) [Pubmed]
  24. Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production. Oshio, K., Song, Y., Verkman, A.S., Manley, G.T. Acta Neurochir. Suppl. (2003) [Pubmed]
  25. Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutant. Merves, M., Krane, C.M., Dou, H., Greinwald, J.H., Menon, A.G., Choo, D. J. Assoc. Res. Otolaryngol. (2003) [Pubmed]
  26. Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Chou, C.L., Ma, T., Yang, B., Knepper, M.A., Verkman, A.S. Am. J. Physiol. (1998) [Pubmed]
  27. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. Song, Y., Ma, T., Matthay, M.A., Verkman, A.S. J. Gen. Physiol. (2000) [Pubmed]
  28. Role of aquaporin water channels in eye function. Verkman, A.S. Exp. Eye Res. (2003) [Pubmed]
  29. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Yang, B., Folkesson, H.G., Yang, J., Matthay, M.A., Ma, T., Verkman, A.S. Am. J. Physiol. (1999) [Pubmed]
WikiGenes - Universities