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Gene Review

AQP1  -  aquaporin 1 (Colton blood group)

Bos taurus

Synonyms: AQP-1, CHIP29
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Disease relevance of Aqp1

  • Binding within the aquaporin pore cannot compensate sufficiently for dehydration of the protonic charge; there is also an electrostatic barrier in the NPA region blocking proton transport [1].
  • The gene for a new bacterial aquaporin, AqpX, was cloned from the pathogenic Gram-negative bacterium BRUCELLA: abortus [2].

High impact information on Aqp1

  • We present several lines of evidence that the activity of this aquaporin is regulated by phosphorylation [3].
  • We conclude that MIP functions as an Aquaporin in lens, but the protein may also have other essential functions [4].
  • In contrast, the third cryo-EM structure that included information from the X-ray structure of the homologous bacterial glycerol facilitator GlpF and that was subsequently refined against cryo-EM AQP1 data, shows a root mean square deviation of 0.9A from the X-ray structure in the helical backbone regions [5].
  • An osmo-regulated H2O-channel, aquaporin-CHIP, from bovine red blood cell membranes was purified and reconstituted with lipids, forming two-dimensional crystalline patches that diffract to about 3.0 A resolution [6].
  • CONCLUSIONS: The identity of the aquaporin, its abundance, and its membrane location suggest that it is a major pathway for fluid flow across endothelial cell membranes [7].

Biological context of Aqp1


Anatomical context of Aqp1


Associations of Aqp1 with chemical compounds

  • When the concentration of dexamethasone was higher than 25 microg/L, the expression of AQP-1 was significantly inhibited (P < 0.05) [11].
  • Differential expression of Na:K:2Cl cotransporter, glucose transporter 1, and aquaporin 1 in freshly isolated and cultured bovine corneal tissues [13].
  • Confocal microscopy of CBCEC in the x, y, and z planes showed rhodamine fluorescence, indicating the presence of AQP1 antibody localized to the apical and basolateral domains of the plasma membrane, but not to the membranes of intracellular compartments or other subcellular locations [12].

Other interactions of Aqp1


Analytical, diagnostic and therapeutic context of Aqp1


  1. Water and ion permeation in bAQP1 and GlpF channels: a kinetic Monte Carlo study. Miloshevsky, G.V., Jordan, P.C. Biophys. J. (2004) [Pubmed]
  2. A functional water channel protein in the pathogenic bacterium Brucella abortus. Rodríguez, M.C., Froger, A., Rolland, J.P., Thomas, D., Agüero, J., Delamarche, C., García-Lobo, J.M. Microbiology (Reading, Engl.) (2000) [Pubmed]
  3. Phosphorylation regulates the water channel activity of the seed-specific aquaporin alpha-TIP. Maurel, C., Kado, R.T., Guern, J., Chrispeels, M.J. EMBO J. (1995) [Pubmed]
  4. Water channel properties of major intrinsic protein of lens. Mulders, S.M., Preston, G.M., Deen, P.M., Guggino, W.B., van Os, C.H., Agre, P. J. Biol. Chem. (1995) [Pubmed]
  5. The structure of the aquaporin-1 water channel: a comparison between cryo-electron microscopy and X-ray crystallography. de Groot, B.L., Engel, A., Grubmüller, H. J. Mol. Biol. (2003) [Pubmed]
  6. Structure of the osmo-regulated H2O-channel, AQP-CHIP, in projection at 3.5 A resolution. Jap, B.K., Li, H. J. Mol. Biol. (1995) [Pubmed]
  7. Molecular identification and immunolocalization of the water channel protein aquaporin 1 in CBCECs. Li, J., Kuang, K., Nielsen, S., Fischbarg, J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  8. Cloning of a novel cDNA homologous to CHIP28 water channel from ocular ciliary epithelium. Patil, R.V., Yang, X., Saito, I., Coca-Prados, M., Wax, M.B. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  9. Regulation of water channel activity of aquaporin 1 by arginine vasopressin and atrial natriuretic peptide. Patil, R.V., Han, Z., Wax, M.B. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  10. Crystallization and preliminary X-ray crystallographic analysis of water channel AQP1. Sui, H., Walian, P.J., Tang, G., Oh, A., Jap, B.K. Acta Crystallogr. D Biol. Crystallogr. (2000) [Pubmed]
  11. Regulatory effect of dexamethasone on aquaporin-1 expression in cultured bovine trabecular meshwork cells. Xiong, X., Miao, J., Xi, Z., Zhang, H., Han, B., Hu, Y. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2005) [Pubmed]
  12. Immunocytochemical localization of aquaporin-1 in bovine corneal endothelial cells and keratocytes. Wen, Q., Diecke, F.P., Iserovich, P., Kuang, K., Sparrow, J., Fischbarg, J. Exp. Biol. Med. (Maywood) (2001) [Pubmed]
  13. Differential expression of Na:K:2Cl cotransporter, glucose transporter 1, and aquaporin 1 in freshly isolated and cultured bovine corneal tissues. Bildin, V.N., Iserovich, P., Fischbarg, J., Reinach, P.S. Exp. Biol. Med. (Maywood) (2001) [Pubmed]
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