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Gene Review:

cdi - center divider

Drosophila melanogaster

Synonyms: 91F, B9.3, CDI/TSKI, CG6027, Cdi, ...

Raymond, K. et al., Ses??, M. et al., Muralidhar, M.G. et al., Egan, E.S. et al.

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High impact information on cdi

We performed an EP screen for negative regulators of this inductive process, and we identified the serine/threonine kinase Center divider (cdi) as a suppressor of the phenotype caused by an activated Sevenless receptor [1].
These results are consistent with Cdi being a specific downstream target of Rac1 [2].
Thus, results from a misexpression screen in the eye led us to a putative novel Rac1-Cdi-Cofilin pathway, regulated by RacGAP(84C), coordinating Drosophila spermatogenesis [2].
In addition, sim protein binds to a small number of additional chromosomal sites, among which are the sites of the 47F gene, and two other genes, Tl and cdi, whose expression also depend on sim function [3].
The DCry gene is located in region 91F of the third chromosome, an interval that does not contain other genes required for circadian rhythmicity [4].

Biological context of cdi

Eye-directed expression of cdi strongly suppressed the phenotypes induced by either RacGAP(84C) gain-of-function or by the dominant negative form of Rac1, Rac1N17 [2].

References

The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye. Ses??, M., Corominas, M., Stocker, H., Heino, T.I., Hafen, E., Serras, F. J. Cell. Sci. (2006) [Pubmed]
A screen for modifiers of RacGAP(84C) gain-of-function in the Drosophila eye revealed the LIM kinase Cdi/TESK1 as a downstream effector of Rac1 during spermatogenesis. Raymond, K., Bergeret, E., Avet-Rochex, A., Griffin-Shea, R., Fauvarque, M.O. J. Cell. Sci. (2004) [Pubmed]
Single-minded regulation of genes in the embryonic midline of the Drosophila central nervous system. Muralidhar, M.G., Callahan, C.A., Thomas, J.B. Mech. Dev. (1993) [Pubmed]
An extraretinally expressed insect cryptochrome with similarity to the blue light photoreceptors of mammals and plants. Egan, E.S., Franklin, T.M., Hilderbrand-Chae, M.J., McNeil, G.P., Roberts, M.A., Schroeder, A.J., Zhang, X., Jackson, F.R. J. Neurosci. (1999) [Pubmed]

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