Gene Review:
sim - single-minded
Drosophila melanogaster
Synonyms:
0483/09, 0716/08, 0899/14, 0953/08, 1002/10, ...
- Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome. Muenke, M., Bone, L.J., Mitchell, H.F., Hart, I., Walton, K., Hall-Johnson, K., Ippel, E.F., Dietz-Band, J., Kvaløy, K., Fan, C.M. Am. J. Hum. Genet. (1995)
- Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. Chrast, R., Scott, H.S., Chen, H., Kudoh, J., Rossier, C., Minoshima, S., Wang, Y., Shimizu, N., Antonarakis, S.E. Genome Res. (1997)
- Single-minded and Down syndrome? Chen, H., Chrast, R., Rossier, C., Gos, A., Antonarakis, S.E., Kudoh, J., Yamaki, A., Shindoh, N., Maeda, H., Minoshima, S. Nat. Genet. (1995)
- The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development. Nambu, J.R., Lewis, J.O., Wharton, K.A., Crews, S.T. Cell (1991)
- The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Crews, S.T., Thomas, J.B., Goodman, C.S. Cell (1988)
- Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system. Thomas, J.B., Crews, S.T., Goodman, C.S. Cell (1988)
- Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression. Morel, V., Le Borgne, R., Schweisguth, F. Dev. Genes Evol. (2003)
- Novel behavioral and developmental defects associated with Drosophila single-minded. Pielage, J., Steffes, G., Lau, D.C., Parente, B.A., Crews, S.T., Strauss, R., Klämbt, C. Dev. Biol. (2002)
- The Snail repressor positions Notch signaling in the Drosophila embryo. Cowden, J., Levine, M. Development (2002)
- Aryl hydrocarbon or dioxin receptor: biologic and toxic responses. Bock, K.W. Rev. Physiol. Biochem. Pharmacol. (1994)
- cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization. Ema, M., Suzuki, M., Morita, M., Hirose, K., Sogawa, K., Matsuda, Y., Gotoh, O., Saijoh, Y., Fujii, H., Hamada, H., Fujii-Kuriyama, Y. Biochem. Biophys. Res. Commun. (1996)
- The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Golembo, M., Raz, E., Shilo, B.Z. Development (1996)
- A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Mayer, U., Nüsslein-Volhard, C. Genes Dev. (1988)
- CNS midline cells contribute to maintenance of the initial dorsoventral patterning of the Drosophila ventral neuroectoderm. Kim, I.O., Kim, I.C., Kim, S., Kwon, Y.K., Han, P.L., Jeon, S.H., Kim, S.H. J. Neurobiol. (2005)
- Regulation of bHLH-PAS protein subcellular localization during Drosophila embryogenesis. Ward, M.P., Mosher, J.T., Crews, S.T. Development (1998)
- Structure-function relationships of EcDOS, a heme-regulated phosphodiesterase from Escherichia coli. Sasakura, Y., Yoshimura-Suzuki, T., Kurokawa, H., Shimizu, T. Acc. Chem. Res. (2006)
- Transcriptional activation domains of the single-minded bHLH protein are required for CNS midline cell development. Franks, R.G., Crews, S.T. Mech. Dev. (1994)
- Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Morel, V., Schweisguth, F. Genes Dev. (2000)
- The CNS midline cells control the spitz class and Egfr signaling genes to establish the proper cell fate of the Drosophila ventral neuroectoderm. Chang, J., Kim, I.O., Ahn, J.S., Kim, S.H. Int. J. Dev. Biol. (2001)
- A function for Egf receptor signaling in expanding the developing brain in Drosophila. Page, D.T. Curr. Biol. (2003)
- Single-minded, Dmef2, Pointed, and Su(H) act on identified regulatory sequences of the roughest gene in Drosophila melanogaster. Apitz, H., Strünkelnberg, M., de Couet, H.G., Fischbach, K.F. Dev. Genes Evol. (2005)
- The jing Zn-finger transcription factor is a mediator of cellular differentiation in the Drosophila CNS midline and trachea. Sedaghat, Y., Miranda, W.F., Sonnenfeld, M.J. Development (2002)
- Commitment of CNS progenitors along the dorsoventral axis of Drosophila neuroectoderm. Udolph, G., Lüer, K., Bossing, T., Technau, G.M. Science (1995)