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Gene Review

Octbeta1R  -  Octopamine beta1 receptor

Drosophila melanogaster

Synonyms: CG6919, DmCG6919, DmOA2, DmOct-beta-1R, DmOctBeta1R, ...
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High impact information on oa2

  • Therefore, the receptor is considered to be an octopamine receptor and is consequently designated Lym oa2 [1].
  • Octopaminergic stimulation of Lym oa2 does not induce changes in intracellular concentrations of cAMP or inositol phosphates [1].
  • However, electrophysiological experiments indicate that octopamine is able to activate a voltage-independent Cl- current in HEK293 cells stably expressing Lym oa2 [1].
  • This group of receptors, DmOct beta1R (CG6919), DmOct beta2R (CG6989) and DmOct beta3R (CG7078) shows homology to vertebrate beta-adrenergic receptors [2].
  • The second gene (Dmoa2) codes for a receptor that specifically activates adenylate cyclase and causes a rise of intracellular cAMP with an EC(50) of approximately 3 x 10(-8) m octopamine [3].


  1. Cloning and expression of a complementary DNA encoding a molluscan octopamine receptor that couples to chloride channels in HEK293 cells. Gerhardt, C.C., Lodder, H.C., Vincent, M., Bakker, R.A., Planta, R.J., Vreugdenhil, E., Kits, K.S., van Heerikhuizen, H. J. Biol. Chem. (1997) [Pubmed]
  2. Identification and characterization of a novel family of Drosophila beta-adrenergic-like octopamine G-protein coupled receptors. Maqueira, B., Chatwin, H., Evans, P.D. J. Neurochem. (2005) [Pubmed]
  3. A family of octopamine [corrected] receptors that specifically induce cyclic AMP production or Ca2+ release in Drosophila melanogaster. Balfanz, S., Strünker, T., Frings, S., Baumann, A. J. Neurochem. (2005) [Pubmed]
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