Gene Review:
HTR4 - 5-hydroxytryptamine (serotonin) receptor 4...
Homo sapiens
Synonyms:
5-HT-4, 5-HT4, 5-HT4R, 5-hydroxytryptamine receptor 4, Serotonin receptor 4
- Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome. Cartier, D., Lihrmann, I., Parmentier, F., Bastard, C., Bertherat, J., Caron, P., Kuhn, J.M., Lacroix, A., Tabarin, A., Young, J., Vaudry, H., Lefebvre, H. J. Clin. Endocrinol. Metab. (2003)
- Expression profile of serotonin4 (5-HT4) receptors in adrenocortical aldosterone-producing adenomas. Cartier, D., Jégou, S., Parmentier, F., Lihrmann, I., Louiset, E., Kuhn, J.M., Bastard, C., Plouin, P.F., Godin, M., Vaudry, H., Lefebvre, H. Eur. J. Endocrinol. (2005)
- Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells. Contesse, V., Lefebvre, H., Lenglet, S., Kuhn, J.M., Delarue, C., Vaudry, H. Can. J. Physiol. Pharmacol. (2000)
- 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Manzke, T., Guenther, U., Ponimaskin, E.G., Haller, M., Dutschmann, M., Schwarzacher, S., Richter, D.W. Science (2003)
- Association between serotonin 4 receptor gene polymorphisms and bipolar disorder in Japanese case-control samples and the NIMH Genetics Initiative Bipolar Pedigrees. Ohtsuki, T., Ishiguro, H., Detera-Wadleigh, S.D., Toyota, T., Shimizu, H., Yamada, K., Yoshitsugu, K., Hattori, E., Yoshikawa, T., Arinami, T. Mol. Psychiatry (2002)
- Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac. Robert, S., Maillet, M., Morel, E., Launay, J.M., Fischmeister, R., Mercken, L., Lezoualc'h, F. FEBS Lett. (2005)
- Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine4 receptor, in gastrointestinal motility. Taniyama, K., Makimoto, N., Furuichi, A., Sakurai-Yamashita, Y., Nagase, Y., Kaibara, M., Kanematsu, T. J. Gastroenterol. (2000)
- Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Lacroix, A., Ndiaye, N., Tremblay, J., Hamet, P. Endocr. Rev. (2001)
- International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Saxena, P.R., Humphrey, P.P. Pharmacol. Rev. (1994)
- Serotonin inhibits Na+/H+ exchange activity via 5-HT4 receptors and activation of PKC alpha in human intestinal epithelial cells. Gill, R.K., Saksena, S., Tyagi, S., Alrefai, W.A., Malakooti, J., Sarwar, Z., Turner, J.R., Ramaswamy, K., Dudeja, P.K. Gastroenterology (2005)
- Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine. Foxx-Orenstein, A.E., Kuemmerle, J.F., Grider, J.R. Gastroenterology (1996)
- The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression. Lötsch, J., Skarke, C., Schneider, A., Hummel, T., Geisslinger, G. Clin. Pharmacol. Ther. (2005)
- Aberrant membrane hormone receptors in incidentally discovered bilateral macronodular adrenal hyperplasia with subclinical Cushing's syndrome. Bourdeau, I., D'Amour, P., Hamet, P., Boutin, J.M., Lacroix, A. J. Clin. Endocrinol. Metab. (2001)
- Modulation of intestinal gas dynamics in healthy human volunteers by the 5-HT receptor agonist tegaserod. Coleski, R., Owyang, C., Hasler, W.L. Am. J. Gastroenterol. (2006)
- The pharmacokinetics of the novel promotile drug, tegaserod, are similar in healthy subjects-male and female, elderly and young. Appel-Dingemanse, S., Horowitz, A., Campestrini, J., Osborne, S., McLeod, J. Aliment. Pharmacol. Ther. (2001)
- Assignment of the human serotonin 4 receptor gene (HTR4) to the long arm of chromosome 5 (5q31-q33). Cichon, S., Kesper, K., Propping, P., Nöthen, M.M. Mol. Membr. Biol. (1998)
- Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects. Li, J., Wang, Y., Zhou, R., Wang, B., Zhang, H., Yang, L., Faraone, S.V. Neurosci. Lett. (2006)
- Expression of serotonin receptors 2B and 4 in human prostate cancer tissue and effects of their antagonists on prostate cancer cell lines. Dizeyi, N., Bjartell, A., Hedlund, P., Taskén, K.A., Gadaleanu, V., Abrahamsson, P.A. Eur. Urol. (2005)
- Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR. Sharif, N.A., Senchyna, M. Mol. Vis. (2006)
- Cloning and expression of a human serotonin 5-HT4 receptor cDNA. Van den Wyngaert, I., Gommeren, W., Verhasselt, P., Jurzak, M., Leysen, J., Luyten, W., Bender, E. J. Neurochem. (1997)
- Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements. Barthet, G., Gaven, F., Framery, B., Shinjo, K., Nakamura, T., Claeysen, S., Bockaert, J., Dumuis, A. J. Biol. Chem. (2005)
- Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Claeysen, S., Sebben, M., Becamel, C., Bockaert, J., Dumuis, A. Mol. Pharmacol. (1999)
- Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. De Ponti, F., Tonini, M. Drugs (2001)
- The role of 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptors in the regulation of gut motility in the ferret. Nagakura, Y., Kiso, T., Ito, H., Miyata, K., Yamaguchi, T. Life Sci. (2000)
- Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium. Molderings, G.J., Frölich, D., Likungu, J., Göthert, M. Naunyn Schmiedebergs Arch. Pharmacol. (1996)
- Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques. Yang, G.B., Qiu, C.L., Zhao, H., Liu, Q., Shao, Y. J. Neuroimmunol. (2006)
- Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin. López-Rodríguez, M.L., Murcia, M., Benhamú, B., Olivella, M., Campillo, M., Pardo, L. J. Comput. Aided Mol. Des. (2001)
- Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization. Claeysen, S., Faye, P., Sebben, M., Lemaire, S., Bockaert, J., Dumuis, A., Taviaux, S. Cytogenet. Cell Genet. (1997)
- Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia. Suzuki, T., Iwata, N., Kitamura, Y., Kitajima, T., Yamanouchi, Y., Ikeda, M., Nishiyama, T., Kamatani, N., Ozaki, N. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003)