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Chemical Compound Review

Normetol     3-(2-amino-1-hydroxy- ethyl)phenol

Synonyms: Norenol, Metacardiol, Norfenefrina, Norfenefrine, Norfenefrinum, ...
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Disease relevance of Zondel

  • The NMH group received norfenefrine-masked hypovolemia but no endotoxin [1].
  • Norfenefrine-masked hypovolemia caused disseminated cardiac cell necrosis independent of endotoxemia (p < .05 vs. ENDO) [1].
  • As we could show in restrained animals, where DL-octopamine was applied topically onto the undesheated mesothoracic ganglion, the complete suppression of the resistance reflex on the motoneuronal level was dose dependent starting at concentrations of 5 x 10(-3) M octopamine [2].
  • Systemic arterial pressure (SAP) was varied with administration of norfenefrine or by hemorrhage in order to obtain SAP/cerebral blood flow (CBF) curves under different conditions [3].
  • Norfenefrine: haemodynamic effects in healthy volunteers at rest and during orthostasis [4].

High impact information on Zondel


Chemical compound and disease context of Zondel


Biological context of Zondel


Anatomical context of Zondel


Associations of Zondel with other chemical compounds


Analytical, diagnostic and therapeutic context of Zondel


  1. Early multiple organ failure after recurrent endotoxemia in the presence of vasoconstrictor-masked hypovolemia. Hinder, F., Stubbe, H.D., Van Aken, H., Baba, H.A., Jahn, U.R., Brodner, G., August, C., Erren, M., Booke, M. Crit. Care Med. (2003) [Pubmed]
  2. Octopamine effects mimick state-dependent changes in a proprioceptive feedback system. Büschges, A., Kittmann, R., Ramirez, J.M. J. Neurobiol. (1993) [Pubmed]
  3. The influence of nimodipine on cerebral blood flow autoregulation and blood-brain barrier. Höllerhage, H.G., Gaab, M.R., Zumkeller, M., Walter, G.F. J. Neurosurg. (1988) [Pubmed]
  4. Norfenefrine: haemodynamic effects in healthy volunteers at rest and during orthostasis. Magometschnigg, D., Stengele, E. Eur. J. Clin. Pharmacol. (1983) [Pubmed]
  5. Effects of denervation of the levels of p-octopamine m-octopamine (norphenylephrine) and phenylethanolamine in rat salivary gland. Robertson, H.A., David, J.C., Danielson, T.J. J. Neurochem. (1977) [Pubmed]
  6. Sympathetic regulation of glucose uptake by the alpha1-adrenoceptor in human obesity. Flechtner-Mors, M., Jenkinson, C.P., Alt, A., Biesalski, H.K., Adler, G., Ditschuneit, H.H. Obes. Res. (2004) [Pubmed]
  7. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. Flechtner-Mors, M., Jenkinson, C.P., Alt, A., Adler, G., Ditschuneit, H.H. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  8. The metabolism of L-m-tyrosine: the use of a putative precursor to investigate the increased production of m-hydroxymandelic acid in phenylketonuria. Hoskins, J.A., Greenway, A.M. Clin. Chim. Acta (1983) [Pubmed]
  9. Norfenefrine in the treatment of female urinary stress incontinence assessed by one-hour pad weighing test. Diernaes, E., Rix, P., Sørensen, T., Alexander, N. Urologia internationalis. (1989) [Pubmed]
  10. In vitro occurrence of m-octopamine in the cultured cephalic ganglion of Locusta migratoria L. after L-dopa administration. Coulon, J.F., Lafon-Cazal, M., David, J.C. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1984) [Pubmed]
  11. Ultrastructural changes in the blood-brain barrier after nimodipine treatment and induced hypertension. Zumkeller, M., Höllerhage, H.G., Reale, E., Dietz, H. Exp. Neurol. (1991) [Pubmed]
  12. Heat shock protein 72 and apoptosis indicate cardiac decompensation during early multiple organ failure in sheep. Baba, H.A., Wohlschlaeger, J., Stubbe, H.D., Grabellus, F., Aken, H.V., Schmitz, K.J., Otterbach, F., Schmid, K.W., August, C., Levkau, B., Hinder, F. Intensive care medicine. (2004) [Pubmed]
  13. Bioavailability of m-octopamine in man related to its metabolism. Hengstmann, J.H., Konen, W., Konen, C., Eichelbaum, M., Dengler, H.J. Eur. J. Clin. Pharmacol. (1975) [Pubmed]
  14. Effects of molindone and fluphenazine on the brain concentration of some phenolic and catecholic amines in the mouse and the rat. Juorio, A.V. Br. J. Pharmacol. (1980) [Pubmed]
  15. The effects of m-octopamine on salivary flow rates and protein secretion by rat submandibular glands. Okina, A., Abe, K., Inuzuka, H., Yano, T., Okina, T., Nakashima, T., Nishiura, T. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1992) [Pubmed]
  16. Evidence for neuronal uptake and release of norfenefrine and evaluation of its alpha-agonistic effects in the rabbit pulmonary artery. Reimann, W. Arzneimittel-Forschung. (1984) [Pubmed]
  17. Age variation in the increase of hypothalamic and brain stem contents of phenylethanolamine m-octopamine and p-octopamine in spontaneously hypertensive rats (SH Kyoto). David, J.C. Experientia (1979) [Pubmed]
  18. Cardiovascular effects of amezinium in humans during passive upright tilt in comparison with norfenefrine and dihydroergotamine. Wilsmann, K., Neugebauer, G., Kessel, R., Lang, E. Arzneimittel-Forschung. (1981) [Pubmed]
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