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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

myo  -  myoglianin

Drosophila melanogaster

Synonyms: BcDNA:LD02307, CG1838, Dmel\CG1838, MYO, Myo, ...
 
 
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High impact information on myoglianin

  • Further we demonstrated that both myoglianin and its most closely related mammalian ligand, myostatin, interacted with a Wit and Baboon (Babo) type II-type I receptor complex to activate TGFbeta/activin-like signaling pathways [1].
  • We also show that the zygotic expression of a recently described Drosophila activin, which maps to the same interval 102 on chromosome 4 as myoglianin, is restricted to the developing central and peripheral nervous system [2].
  • Northern analysis shows that myoglianin is expressed throughout the Drosophila life cycle [2].
  • Between stages 11 and 14, myoglianin mRNA is exclusively detected in glial cells and their precursors [2].

References

  1. The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways. Lee-Hoeflich, S.T., Zhao, X., Mehra, A., Attisano, L. FEBS Lett. (2005) [Pubmed]
  2. Sequence and expression of myoglianin, a novel Drosophila gene of the TGF-beta superfamily. Lo, P.C., Frasch, M. Mech. Dev. (1999) [Pubmed]
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