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Gene Review

MSTN  -  myostatin

Gallus gallus

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Disease relevance of GDF8

  • Using the allele substitution effect model, the myostatin SNPs were found to have significant (P < 0.031) associations with growth, mortality, blood oxygen and hen antibody titer to infectious bursal disease virus vaccine, although the associations were not often consistent across lines [1].

High impact information on GDF8


Biological context of GDF8


Anatomical context of GDF8


Other interactions of GDF8

  • In the PM muscle, both IGF-I and MSTN mRNA levels increased between 0 and 2 days of age in the fed group, while they remained low in the unfed one [8].
  • In addition, the expression alteration of skeletal muscle-specific cardiac ankyrin repeat protein and the bcl-2 related anti-apoptotic protein Nr-13 suggests possible unique roles for myostatin in regulating myogenesis by controlling cofactors participated transcriptional regulation and apoptosis [6].

Analytical, diagnostic and therapeutic context of GDF8


  1. Associations of myostatin gene polymorphisms with performance and mortality traits in broiler chickens. Ye, X., Brown, S.R., Nones, K., Coutinho, L.L., Dekkers, J.C., Lamont, S.J. Genet. Sel. Evol. (2007) [Pubmed]
  2. The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis. Amthor, H., Huang, R., McKinnell, I., Christ, B., Kambadur, R., Sharma, M., Patel, K. Dev. Biol. (2002) [Pubmed]
  3. Temporal expression of growth factor genes during myogenesis of satellite cells derived from the biceps femoris and pectoralis major muscles of the chicken. Kocamis, H., McFarland, D.C., Killefer, J. J. Cell. Physiol. (2001) [Pubmed]
  4. Gene silencing of myostatin in differentiation of chicken embryonic myoblasts by small interfering RNA. Sato, F., Kurokawa, M., Yamauchi, N., Hattori, M.A. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  5. Temporal and spatial expression of the myostatin gene during chicken embryo development. Castelhano-Barbosa, E.C., Gabriel, J.E., Alvares, L.E., Monteiro-Vitorello, C.B., Coutinho, L.L. Growth, development, and aging : GDA. (2005) [Pubmed]
  6. Identification of gene expression modifications in myostatin-stimulated myoblasts. Yang, W., Zhang, Y., Ma, G., Zhao, X., Chen, Y., Zhu, D. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  7. Comparison of chicken genotypes: myofiber number in pectoralis muscle and myostatin ontogeny. Scheuermann, G.N., Bilgili, S.F., Tuzun, S., Mulvaney, D.R. Poult. Sci. (2004) [Pubmed]
  8. Nutrient supply enhances both IGF-I and MSTN mRNA levels in chicken skeletal muscle. Guernec, A., Chevalier, B., Duclos, M.J. Domest. Anim. Endocrinol. (2004) [Pubmed]
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