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Gene Review

Mstn  -  myostatin

Rattus norvegicus

Synonyms: GDF-8, Gdf8, Growth/differentiation factor 8, Myostatin
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Disease relevance of Gdf8


High impact information on Gdf8


Chemical compound and disease context of Gdf8

  • We hypothesized that glutamine effect on reversal of GC-induced muscle atrophy is mediated in part by suppression of myostatin [2].

Biological context of Gdf8


Anatomical context of Gdf8

  • Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat [8].
  • Both conditioned media from stretched myocytes and exogenous administration of IGF-1 recombinant protein to the non-stretched myocytes increased myostatin protein expression similar to that seen after cyclic stretch [7].
  • Furthermore, crushed muscle extract prepared from regenerating skeletal muscle had induced myostatin mRNA expression in skeletal muscle-derived fibroblasts in a dose-dependent manner [11].
  • In C2C12 myoblast cells, addition of glutamine to dexamethasone prevented the hyperexpression of myostatin induced by dexamethasone [2].
  • RESULTS: No significant changes in IGF-I and GLUT4 mRNA levels were found in any of the muscles analysed. mRNA contents of myostatin were significantly reduced in gastrocnemius and vastus lateralis but not in soleus [12].

Associations of Gdf8 with chemical compounds


Other interactions of Gdf8


Analytical, diagnostic and therapeutic context of Gdf8

  • However, the expression of myostatin in chronic heart failure resulting from volume-overload and after treatment with beta-blockers is little known [13].
  • METHODS: We measured (Northern Blot) myostatin transcript levels in muscle groups with different fiber composition in streptozotocin-diabetic male rats receiving one of the following treatments for eight weeks: (1) control (C); (2) diabetes without treatment (DM); (3) diabetes with once-daily slow-acting insulin treatment (INS) [14].
  • Myostatin expression was measured by Northern and Western blots, and was compared with glyceraldehyde-3-phosphate dehydrogenase [2].


  1. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Ma, K., Mallidis, C., Bhasin, S., Mahabadi, V., Artaza, J., Gonzalez-Cadavid, N., Arias, J., Salehian, B. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  2. The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression. Salehian, B., Mahabadi, V., Bilas, J., Taylor, W.E., Ma, K. Metab. Clin. Exp. (2006) [Pubmed]
  3. Long term adrenal insufficiency induces skeletal muscle atrophy and increases the serum levels of active form myostatin in rat serum. Hosoyama, T., Tachi, C., Yamanouchi, K., Nishihara, M. Zool. Sci. (2005) [Pubmed]
  4. Increased myostatin synthesis in rat gastrocnemius muscles under high-protein diet. Nakazato, K., Hirose, T., Song, H. International journal of sport nutrition and exercise metabolism. (2006) [Pubmed]
  5. Ectopic expression of myostatin induces atrophy of adult skeletal muscle by decreasing muscle gene expression. Durieux, A.C., Amirouche, A., Banzet, S., Koulmann, N., Bonnefoy, R., Pasdeloup, M., Mouret, C., Bigard, X., Peinnequin, A., Freyssenet, D. Endocrinology (2007) [Pubmed]
  6. Modulation of myostatin expression during modified muscle use. Wehling, M., Cai, B., Tidball, J.G. FASEB J. (2000) [Pubmed]
  7. Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes. Shyu, K.G., Ko, W.H., Yang, W.S., Wang, B.W., Kuan, P. Cardiovasc. Res. (2005) [Pubmed]
  8. Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Dasarathy, S., Dodig, M., Muc, S.M., Kalhan, S.C., McCullough, A.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  9. Expression of tropism-related genes in regenerating skeletal muscle of rats treated with cyclosporin-A. Miyabara, E.H., Aoki, M.S., Soares, A.G., Moriscot, A.S. Cell Tissue Res. (2005) [Pubmed]
  10. Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Morissette, M.R., Cook, S.A., Foo, S., McKoy, G., Ashida, N., Novikov, M., Scherrer-Crosbie, M., Li, L., Matsui, T., Brooks, G., Rosenzweig, A. Circ. Res. (2006) [Pubmed]
  11. Expression of myostatin gene in regenerating skeletal muscle of the rat and its localization. Yamanouchi, K., Soeta, C., Naito, K., Tojo, H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  12. Short-term endurance training results in a muscle-specific decrease of myostatin mRNA content in the rat. Matsakas, A., Friedel, A., Hertrampf, T., Diel, P. Acta Physiol. Scand. (2005) [Pubmed]
  13. Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure. Shyu, K.G., Lu, M.J., Wang, B.W., Sun, H.Y., Chang, H. Eur. J. Clin. Invest. (2006) [Pubmed]
  14. Myostatin expression is not altered by insulin deficiency and replacement in streptozotocin-diabetic rat skeletal muscles. Barazzoni, R., Zanetti, M., Bosutti, A., Stebel, M., Cattin, L., Biolo, G., Guarnieri, G. Clinical nutrition (Edinburgh, Scotland) (2004) [Pubmed]
  15. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Lang, C.H., Frost, R.A., Svanberg, E., Vary, T.C. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  16. Asynchronous functional, cellular and transcriptional changes after a bout of eccentric exercise in the rat. Peters, D., Barash, I.A., Burdi, M., Yuan, P.S., Mathew, L., Fridén, J., Lieber, R.L. J. Physiol. (Lond.) (2003) [Pubmed]
  17. The effect of 30 minutes of passive stretch of the rat soleus muscle on the myogenic differentiation, myostatin, and atrogin-1 gene expressions. Gomes, A.R., Soares, A.G., Peviani, S., Nascimento, R.B., Moriscot, A.S., Salvini, T.F. Archives of physical medicine and rehabilitation. (2006) [Pubmed]
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