High impact information on sbr

• Molecular Population Genetics of the alpha-Esterase5 Gene Locus in Original and Colonized Populations of Drosophila buzzatii and Its Sibling Drosophila koepferae [1].
• NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila [2].
• We show that sbr is essential for the nuclear export of all mRNAs tested in a wide range of tissues and times in development [3].
• As adults, sbr flies have smaller and thinner bristles with a reduced diameter, suggesting a defective cytoskeleton within [4].
• small bristles is required for the morphogenesis of multiple tissues during Drosophila development [4].

Biological context of sbr

• The Drosophila genome encodes one p15 homolog and four putative NXF proteins (NXF1 to NXF4) [2].
• We have investigated the localization of the transposable genetic elements mdg1, 412, mdg3, gypsy (mdg4), copia and P in the X chromosomes of the MS and in the mutant lines y, ct, sbt derived from it by in situ hybridization [5].
• Fast growing M+ clones, labelled with y and/or mwh, were produced by X-irradiation of the following genotypes: y; scJ4(y+)M(3)i55/mwh jv M+ (series I), and l(1)ts 504 sn3 l(1)ts 5697/ In(1)wvC; M(3)i55/mwh M+ (series II) [6].

Other interactions of sbr

• We conclude that Dm NXF1/p15 heterodimers only (but not NXF2-NXF4) mediate the export of the majority of mRNAs in Drosophila cells and that the other members of the NXF family play more specialized or different roles [2].

Analytical, diagnostic and therapeutic context of sbr

• High resolution and sensitive in situ hybridization detect the rapid accumulation of individual mRNA species in sbr mutant nuclei in particles that are distinct from nascent transcript foci and resemble wild-type export intermediates [3].

References