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Gene Review

Nxf1  -  nuclear RNA export factor 1

Mus musculus

Synonyms: Mex67, Mvb1, Nuclear RNA export factor 1, TAP, Tap, ...
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Disease relevance of Nxf1

  • A natural allele of Nxf1 suppresses retrovirus insertional mutations [1].
  • The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpn(vb) tremor mutation and the Eya1(BOR) model of human branchiootorenal syndrome [1].
  • The absence of female-specific Tap gene defects also indicates this cannot account for the reduced male incidence of IDDM in some NOD mouse colonies [2].
  • Investigation of the role of type IV Aeromonas pilus (Tap) in the pathogenesis of Aeromonas gastrointestinal infection [3].
  • However, the Mason-Pfizer monkey virus (MPMV) has been shown to encode a structured RNA sequence, termed the constitutive transport element (CTE), that recruits a cellular RNA export factor termed Tap [4].

High impact information on Nxf1

  • Positional complementation cloning identifies Mvb1 as the nuclear export factor Nxf1, providing an unexpected link between the mRNA export receptor and pre-mRNA processing [1].
  • Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen [5].
  • We performed a complete genome scan and mapped a major suppressor locus (Mvb-1) to proximal chromosome 19 [6].
  • TLP was identified as a gene product which is upregulated in a thymus in which selection of T cells is occurring (Rag(-/-) OT-1) compared to its expression in a thymus in which selection is blocked at the CD4+ CD8+ stage of T-cell development (Rag(-/-) Tap(-/-) OT-1) [7].
  • Thus, the H2g7 haplotype is not characterized by a Tap gene defect that only impairs the inductive phase of the immune response [2].

Biological context of Nxf1


Analytical, diagnostic and therapeutic context of Nxf1

  • Tocopherol-associated protein (Tap) was one of the induced genes, and the Tap induction in response to activin A treatment was confirmed by real-time RT-PCR analyses [10].


  1. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Floyd, J.A., Gold, D.A., Concepcion, D., Poon, T.H., Wang, X., Keithley, E., Chen, D., Ward, E.J., Chinn, S.B., Friedman, R.A., Yu, H.T., Moriwaki, K., Shiroishi, T., Hamilton, B.A. Nat. Genet. (2003) [Pubmed]
  2. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Serreze, D.V., Gallichan, W.S., Snider, D.P., Croitoru, K., Rosenthal, K.L., Leiter, E.H., Christianson, G.J., Dudley, M.E., Roopenian, D.C. Diabetes (1996) [Pubmed]
  3. Investigation of the role of type IV Aeromonas pilus (Tap) in the pathogenesis of Aeromonas gastrointestinal infection. Kirov, S.M., Barnett, T.C., Pepe, C.M., Strom, M.S., Albert, M.J. Infect. Immun. (2000) [Pubmed]
  4. Structural and functional analysis of the avian leukemia virus constitutive transport element. Yang, J., Cullen, B.R. RNA (1999) [Pubmed]
  5. Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen. Aldrich, C.J., DeCloux, A., Woods, A.S., Cotter, R.J., Soloski, M.J., Forman, J. Cell (1994) [Pubmed]
  6. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Hamilton, B.A., Smith, D.J., Mueller, K.L., Kerrebrock, A.W., Bronson, R.T., van Berkel, V., Daly, M.J., Kruglyak, L., Reeve, M.P., Nemhauser, J.L., Hawkins, T.L., Rubin, E.M., Lander, E.S. Neuron (1997) [Pubmed]
  7. Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity. Kirchner, J., Forbush, K.A., Bevan, M.J. Mol. Cell. Biol. (2001) [Pubmed]
  8. Molecular cloning and functional characterization of mouse Nxf family gene products. Sasaki, M., Takeda, E., Takano, K., Yomogida, K., Katahira, J., Yoneda, Y. Genomics (2005) [Pubmed]
  9. HLA-B27 and other predisposing factors in spondyloarthropathies. Khare, S.D., Luthra, H.S., David, C.S. Current opinion in rheumatology. (1998) [Pubmed]
  10. Identification of tocopherol-associated protein as an activin/TGF-beta-inducible gene in mast cells. Funaba, M., Murakami, M., Ikeda, T., Ogawa, K., Tsuchida, K., Sugino, H. Biochim. Biophys. Acta (2006) [Pubmed]
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