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Gene Review:

fray - frayed

Drosophila melanogaster

Synonyms: 4624, CG7693, Dmel\CG7693, Dosr1, STE20-like/SPAK, ...

Ruan, W. et al., Huang, J. et al., Ruan, W. et al., Houalla, T. et al., Paricio, N. et al.

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High impact information on fray

In Drosophila, these two processes are regulated by a pathway involving the Ste20-like kinase Hippo (Hpo) and the NDR family kinase Warts (Wts; also called Lats) [1].
Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila [2].
We now demonstrate that Dock interacts with the Ste20-like kinase Misshapen (Msn) in the Drosophila photoreceptor (R cell) growth cones [3].
The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling [4].
The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye [5].

Anatomical context of fray

The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility [3].

References

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Huang, J., Wu, S., Barrera, J., Matthews, K., Pan, D. Cell (2005) [Pubmed]
Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila. Ruan, W., Long, H., Vuong, D.H., Rao, Y. Neuron (2002) [Pubmed]
The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility. Ruan, W., Pang, P., Rao, Y. Neuron (1999) [Pubmed]
The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling. Paricio, N., Feiguin, F., Boutros, M., Eaton, S., Mlodzik, M. EMBO J. (1999) [Pubmed]
The Ste20-like kinase misshapen functions together with Bicaudal-D and dynein in driving nuclear migration in the developing drosophila eye. Houalla, T., Hien Vuong, D., Ruan, W., Suter, B., Rao, Y. Mech. Dev. (2005) [Pubmed]

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AgaP_AGAP006715	Anopheles gambiae str. PEST
OXSR1	Bos taurus
gck-3	Caenorhabditis elegans
OXSR1	Canis lupus familiaris
OXSR1	Gallus gallus
OXSR1	Homo sapiens
OXSR1	Macaca mulatta
Oxsr1	Mus musculus
OXSR1	Pan troglodytes
Oxsr1	Rattus norvegicus
stk39	Xenopus (Silurana) tropicalis

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