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Gene Review

dock  -  dreadlocks

Drosophila melanogaster

Synonyms: CG3727, DOCK, Dm0447, Dmel\CG3727, Dock, ...
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High impact information on dock


Biological context of dock

  • Detailed analyses of the mutant phenotypes in whole mutants and in small multicellular clones indicate that Dock and Pak do not control olfactory neuron (ON) differentiation, but specifically regulate multiple aspects of axon trajectories to guide them to their cognate glomeruli [5].
  • Tyrosine phosphorylation of Dscam recruits the Src homology 2 domain of the adaptor protein Dock to the receptor [6].
  • The Drosophila adapter, Dreadlocks (Dock), the homolog of mammalian Nck containing three N-terminal SH3 domains and a single SH2 domain, is highly specialized for growth-cone guidance [7].
  • The Dmel/Nck gene maps to chromosome 3 (93A-B) using in situ hybridization to polytene chromosomes, the same position as the Na(+)-K(+)-ATPase, a related transporter [8].
  • Alternative splicing for the Dmel/Nck gene is suggested in the same intracellular loop region as demonstrated for NCX1 [8].

Anatomical context of dock

  • We now show that Msn likewise interacts with Dreadlocks (Dock), the Drosophila homolog of Nck. dock is required for the correct targeting of photoreceptor axons [9].
  • Concomitant loss of both maternally and zygotically derived Dock dramatically enhances these central nervous system defects, but does not increase the delay in RP3 synaptogenesis [10].
  • These results indicate that Dock facilitates synapse formation by the RP3 motoneuron and is also required for guidance of some interneuronal axons The involvement of Dock in the conversion of the RP3 growth cone into a presynaptic terminal may reflect a role for Dock-mediated signaling in remodeling of the growth cone's cytoskeleton [10].

Associations of dock with chemical compounds

  • We report here that the SH2/SH3 adapter Dock and the serine/threonine kinase Pak are necessary for the precise guidance of olfactory axons [5].

Physical interactions of dock


Other interactions of dock

  • Pak signaling within this pathway is specified by a required interaction with the adaptor protein Dreadlocks (Dock) [11].
  • DInR functions as a guidance receptor for the adapter protein Dock/Nck [12].
  • Lamellae are initiated by parallel and partially redundant signaling pathways involving Rac GTPases and the adaptor protein Nck, which stimulate SCAR, an Arp2/3 activator [13].

Analytical, diagnostic and therapeutic context of dock

  • Immune precipitations of Dock also co-precipitate two tyrosine-phosphorylated proteins having molecular masses of 190 and 145 kDa [14].


  1. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Schmucker, D., Clemens, J.C., Shu, H., Worby, C.A., Xiao, J., Muda, M., Dixon, J.E., Zipursky, S.L. Cell (2000) [Pubmed]
  2. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Hing, H., Xiao, J., Harden, N., Lim, L., Zipursky, S.L. Cell (1999) [Pubmed]
  3. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Garrity, P.A., Rao, Y., Salecker, I., McGlade, J., Pawson, T., Zipursky, S.L. Cell (1996) [Pubmed]
  4. The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility. Ruan, W., Pang, P., Rao, Y. Neuron (1999) [Pubmed]
  5. Dock and Pak regulate olfactory axon pathfinding in Drosophila. Ang, L.H., Kim, J., Stepensky, V., Hing, H. Development (2003) [Pubmed]
  6. Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Muda, M., Worby, C.A., Simonson-Leff, N., Clemens, J.C., Dixon, J.E. Biochem. J. (2002) [Pubmed]
  7. Domain requirements for the Dock adapter protein in growth- cone signaling. Rao, Y., Zipursky, S.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Na+/Ca2+ exchanger in Drosophila: cloning, expression, and transport differences. Ruknudin, A., Valdivia, C., Kofuji, P., Lederer, W.J., Schulze, D.H. Am. J. Physiol. (1997) [Pubmed]
  9. The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals. Su, Y.C., Maurel-Zaffran, C., Treisman, J.E., Skolnik, E.Y. Mol. Cell. Biol. (2000) [Pubmed]
  10. The Drosophila SH2-SH3 adapter protein Dock is expressed in embryonic axons and facilitates synapse formation by the RP3 motoneuron. Desai, C.J., Garrity, P.A., Keshishian, H., Zipursky, S.L., Zinn, K. Development (1999) [Pubmed]
  11. Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Albin, S.D., Davis, G.W. J. Neurosci. (2004) [Pubmed]
  12. Axons guided by insulin receptor in Drosophila visual system. Song, J., Wu, L., Chen, Z., Kohanski, R.A., Pick, L. Science (2003) [Pubmed]
  13. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. Rogers, S.L., Wiedemann, U., Stuurman, N., Vale, R.D. J. Cell Biol. (2003) [Pubmed]
  14. A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance. Clemens, J.C., Ursuliak, Z., Clemens, K.K., Price, J.V., Dixon, J.E. J. Biol. Chem. (1996) [Pubmed]
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