Gene Review:
NGB - neuroglobin
Canis lupus familiaris
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Disease relevance of NGB
- Immunohistochemical analysis of canine retinas demonstrated Ngb immunoreactivity (IR) in the ganglion cell layer (GCL), inner (INL) and outer (ONL) nuclear layers, inner (IPL) and outer plexiform (OPL) layers, photoreceptor inner segments (IS), and retinal pigment epithelium (RPE) [1].
High impact information on NGB
- Immunoblot analysis was performed to verify antibody specificity and the presence of Ngb and Cygb in canine tissues [1].
- CONCLUSIONS: Ngb and Cygb are widely distributed in retinal neurons and RPE, but not in glial cells of the canine retina [1].
Analytical, diagnostic and therapeutic context of NGB
- Double-labeling immunohistochemistry was performed with the Ngb and Cygb antibodies along with antibodies against neuronal (MAP-2, class III beta-tubulin (TUJ1), PKCalpha, and calretinin) and glial antigens (vimentin and CRALBP) [1].
References
- Neuroglobin and cytoglobin: oxygen-binding proteins in retinal neurons. Ostojić, J., Sakaguchi, D.S., de Lathouder, Y., Hargrove, M.S., Trent, J.T., Kwon, Y.H., Kardon, R.H., Kuehn, M.H., Betts, D.M., Grozdanić, S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
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