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Gene Review

Ngb  -  neuroglobin

Rattus norvegicus

Synonyms: Neuroglobin
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Disease relevance of Ngb


High impact information on Ngb


Biological context of Ngb


Anatomical context of Ngb

  • When artificially over-expressed, NGB reduces the infarct size observed after transient Middle Cerebral Artery occlusion (tMCAo) in rats [5].
  • NGB expression was mainly confined to the hypothalamus and amygdala [5].
  • Neuroglobin (NGB) is a recently characterized heme globin expressed primarily in retinal nerve cells and at very low levels in endocrine-active regions of vertebrate brains [5].

Analytical, diagnostic and therapeutic context of Ngb

  • To further study the characterization of this gene, the coding region of rat neuroglobin (GenBank Accession No. AF333245) was cloned by using degeneracy PCR [7].
  • Post-ischemic expression of NGB and the neuronal marker NeuN was studied using free-floating immunohistochemistry [5].


  1. Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. Li, R.C., Lee, S.K., Pouranfar, F., Brittian, K.R., Clair, H.B., Row, B.W., Wang, Y., Gozal, D. Brain Res. (2006) [Pubmed]
  2. Neuron-specific expression of neuroglobin in mammals. Laufs, T.L., Wystub, S., Reuss, S., Burmester, T., Saaler-Reinhardt, S., Hankeln, T. Neurosci. Lett. (2004) [Pubmed]
  3. Neuroglobin protects the brain from experimental stroke in vivo. Sun, Y., Jin, K., Peel, A., Mao, X.O., Xie, L., Greenberg, D.A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Divergent distribution in vascular and avascular mammalian retinae links neuroglobin to cellular respiration. Bentmann, A., Schmidt, M., Reuss, S., Wolfrum, U., Hankeln, T., Burmester, T. J. Biol. Chem. (2005) [Pubmed]
  5. Does neuroglobin protect neurons from ischemic insult? A quantitative investigation of neuroglobin expression following transient MCAo in spontaneously hypertensive rats. Hundahl, C., Kelsen, J., Kjaer, K., Rønn, L.C., Weber, R.E., Geuens, E., Hay-Schmidt, A., Nyengaard, J.R. Brain Res. (2006) [Pubmed]
  6. Neuroglobin, a new oxygen binding protein is present in the carotid body and increases after chronic intermittent hypoxia. Di Giulio, C., Bianchi, G., Cacchio, M., Artese, L., Piccirilli, M., Verratti, V., Valerio, R., Iturriaga, R. Adv. Exp. Med. Biol. (2006) [Pubmed]
  7. Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin. Zhang, C., Wang, C., Deng, M., Li, L., Wang, H., Fan, M., Xu, W., Meng, F., Qian, L., He, F. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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