The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ngb  -  neuroglobin

Mus musculus

Synonyms: Neuroglobin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ngb


High impact information on Ngb

  • These findings extend prior evidence for cytoprotection by Ngb and suggest both direct (parenchymatous) and indirect (vasomotor) protective mechanisms [1].
  • Ngb overexpression was associated with enhanced expression of endothelial nitric oxide synthase in vascular endothelial cells [1].
  • Steady-state amperometric experiments show that Ngb is devoid of O2 reductase and NO reductase activities [4].
  • Here, we present the x-ray structure of CO-bound ferrous murine Ngb at 1.7 A and a comparison with the 1.5-A structure of ferric bis-histidine Ngb [5].
  • We have also used Fourier transform IR spectroscopy of WT and mutant CO-ligated Ngb to examine structural heterogeneity in the active site [5].

Biological context of Ngb


Anatomical context of Ngb


Associations of Ngb with chemical compounds


Other interactions of Ngb

  • In contrast, neuroglobin immunoreactivity was detected in specific brain regions with varying intensities and in the islet of Langerhans in the pancreas [13].

Analytical, diagnostic and therapeutic context of Ngb

  • In situ hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed ubiquitously in all analyzed tissues [13].
  • Based on the ligand-linked conformational changes discovered by crystallography, the pathways of the reactions with O2 and NO provide a framework that may account for the involvement of Ngb in controlling the activation of a protective signaling mechanism [4].
  • To characterize the structure/function relationships of this new heme protein, we have used resonance Raman spectroscopy to determine the structure of the heme environment in Ngb from mice [14].
  • The RT-PCR data supported the lack of differences in brain Ngb levels between normal and oxygen-deprived animals [7].
  • In the retina, Ngb localization by immunohistochemistry was confined to the inner segments of the photoreceptors, the plexiform layers and the ganglion cells [7].


  1. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Khan, A.A., Wang, Y., Sun, Y., Mao, X.O., Xie, L., Miles, E., Graboski, J., Chen, S., Ellerby, L.M., Jin, K., Greenberg, D.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Divergent distribution of cytoglobin and neuroglobin in the murine eye. Schmidt, M., Laufs, T., Reuss, S., Hankeln, T., Burmester, T. Neurosci. Lett. (2005) [Pubmed]
  3. Effect of aging on neuroglobin expression in rodent brain. Sun, Y., Jin, K., Mao, X.O., Xie, L., Peel, A., Childs, J.T., Logvinova, A., Wang, X., Greenberg, D.A. Neurobiol. Aging (2005) [Pubmed]
  4. Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes. Brunori, M., Giuffrè, A., Nienhaus, K., Nienhaus, G.U., Scandurra, F.M., Vallone, B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity. Vallone, B., Nienhaus, K., Matthes, A., Brunori, M., Nienhaus, G.U. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Presence of neuroglobin in cultured astrocytes. Chen, X.Q., Qin, L.Y., Zhang, C.G., Yang, L.T., Gao, Z., Liu, S., Lau, L.T., Fung, Y.W., Greenberg, D.A., Yu, A.C. Glia (2005) [Pubmed]
  7. Effects of short-term hypoxia on neuroglobin levels and localization in mouse brain tissues. Hundahl, C., Stoltenberg, M., Fago, A., Weber, R.E., Dewilde, S., Fordel, E., Danscher, G. Neuropathol. Appl. Neurobiol. (2005) [Pubmed]
  8. Expression analysis of neuroglobin mRNA in rodent tissues. Reuss, S., Saaler-Reinhardt, S., Weich, B., Wystub, S., Reuss, M.H., Burmester, T., Hankeln, T. Neuroscience (2002) [Pubmed]
  9. How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina. Schmidt, M., Giessl, A., Laufs, T., Hankeln, T., Wolfrum, U., Burmester, T. J. Biol. Chem. (2003) [Pubmed]
  10. Ligand binding and protein dynamics in neuroglobin. Kriegl, J.M., Bhattacharyya, A.J., Nienhaus, K., Deng, P., Minkow, O., Nienhaus, G.U. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  11. Nitric oxide binding properties of neuroglobin. A characterization by EPR and flash photolysis. Van Doorslaer, S., Dewilde, S., Kiger, L., Nistor, S.V., Goovaerts, E., Marden, M.C., Moens, L. J. Biol. Chem. (2003) [Pubmed]
  12. The heme environment of mouse neuroglobin: histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography. Walker, F.A. J. Biol. Inorg. Chem. (2006) [Pubmed]
  13. A globin in the nucleus! Geuens, E., Brouns, I., Flamez, D., Dewilde, S., Timmermans, J.P., Moens, L. J. Biol. Chem. (2003) [Pubmed]
  14. The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket. Couture, M., Burmester, T., Hankeln, T., Rousseau, D.L. J. Biol. Chem. (2001) [Pubmed]
WikiGenes - Universities