Gene Review:
GLUT8 - glucose transporter 8
Ovis aries
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Disease relevance of GLUT8
- The objective of this study was to characterize GLUT8 in the ovine placenta and determine if differences in mRNA and protein concentrations occur in an ovine model of intrauterine growth restriction (IUGR) [1].
- GLUT8 mRNA and protein concentrations at 135 days gestational age were decreased by 34.8 per cent and 21.8 per cent, respectively (P<0.05), in an ovine placental insufficiency model of IUGR [1].
High impact information on GLUT8
- Identification of GLUT8 in the ovine placenta indicates a potential role for GLUT8 in mediating glucose uptake within the placenta and transport to the fetus [1].
- Western immunoblots with an affinity-purified anti-mouse GLUT8 antiserum detected GLUT8 in late gestation ovine placenta plasma membranes [1].
- GLUT8 was immunolocalized to the chorionic epithelial layer and uterine epithelial cells from mid to late gestation [1].
- Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses [1].
- A GLUT8 partial mRNA was generated, which shares 95 per cent identity with bovine GLUT8 nucleotide sequence [1].
Associations of GLUT8 with chemical compounds
- Further studies are necessary to confirm this hypothesis and whether the observed decreases in GLUT8 in the PI-IUGR model might contribute, at least in part, to the placental glucose transport deficit that occurs in this model [1].
References
- Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses. Limesand, S.W., Regnault, T.R., Hay, W.W. Placenta (2004) [Pubmed]
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