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Gene Review:

psmb9 - proteasome (prosome, macropain) subunit,...

Xenopus (Silurana) tropicalis

Synonyms: LMP2, MHC-linked, ring12

Kaufman, J.F. et al., Shum, B.P. et al., Ohta, Y. et al., Flajnik, M.F. et al.

Ohta, Powis, Lohr, Nonaka, Pasquier, Flajnik,

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High impact information on LMP2

Thus, there is a strong pressure in Xenopus to maintain very few MHC-linked class I genes, exemplified both by the number of class I genes per MHC haplotype and by the number of class la genes per organism [1].
Immunofluorescence detects an otherwise uncharacterized MHC-linked alloantigen on tadpole thymic epithelium from the earliest stages of thymus differentiation [2].
This xenoantiserum inhibits bidirectional Xenopus MLR (but not PHA-stimulation), recognizes the same molecules as certain MHC-linked Xenopus alloantisera, and immunoprecipitates class II molecules from Xenopus cells consistent with the tissue distribution of mammalian class II molecules [3].
In the frog Xenopus, MHC class I antigen presentation and processing genes (the immunoproteasome LMP2 and LMP7 and the transporter TAP1 and TAP2) seem to be closely linked in a primordial organization [4].

References

Isolation of a classical MHC class I cDNA from an amphibian. Evidence for only one class I locus in the Xenopus MHC. Shum, B.P., Avila, D., Du Pasquier, L., Kasahara, M., Flajnik, M.F. J. Immunol. (1993) [Pubmed]
Major histocompatibility complex-encoded class I molecules are absent in immunologically competent Xenopus before metamorphosis. Flajnik, M.F., Kaufman, J.F., Hsu, E., Manes, M., Parisot, R., Du Pasquier, L. J. Immunol. (1986) [Pubmed]
Xenopus MHC class II molecules. I. Identification and structural characterization. Kaufman, J.F., Flajnik, M.F., Du Pasquier, L., Riegert, P. J. Immunol. (1985) [Pubmed]
Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes. Ohta, Y., Powis, S.J., Lohr, R.L., Nonaka, M., Pasquier, L.D., Flajnik, M.F. Eur. J. Immunol. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PSMB9	Bos taurus
PSMB9	Canis lupus familiaris
psmb9a	Danio rerio
PSMB9	Homo sapiens
PSMB9	Macaca mulatta
Psmb9	Mus musculus
PSMB9	Pan troglodytes
Psmb9	Rattus norvegicus

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