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Gene Review

Psmb9  -  proteasome (prosome, macropain) subunit,...

Mus musculus

Synonyms: LMP-2d, Lmp-2, Lmp2, Low molecular mass protein 2, Macropain chain 7, ...
 
 
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Disease relevance of Psmb9

 

High impact information on Psmb9

 

Biological context of Psmb9

 

Anatomical context of Psmb9

 

Other interactions of Psmb9

  • By making deletions of the promoter, we determined that only the proximal GAS box is required for LPS induction of Tap1 and Lmp2 [6].
  • These data suggest that NOD proteasome dysfunction is due to a tissue- and developmental-stage-specific defect in expression of the MHC-linked Lmp2 gene, resulting in altered transcription factor NF-kappaB activity, and that this defect contributes to pathogenesis in NOD mice [8].
  • Twenty-three breakpoints were confined within 5.4 kb in the Lmp-2 hotspot, and six breakpoints from the cas4 cross were located in the Pb hotspot, which we have now confined to a 15 kb segment [9].
  • Sequence analysis of the mouse gene encoding DELTA, designated Lmp19, indicates that it consists of six exons and five introns, similar to the Lmp2 gene [10].

References

  1. Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (Lmp-2). Zhou, P., Cao, H., Smart, M., David, C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Genomic organization of the mouse Lmp-2 gene and characteristic structure of its promoter. Kishi, F., Suminami, Y., Monaco, J.J. Gene (1993) [Pubmed]
  3. Crossover and noncrossover pathways in mouse meiosis. Guillon, H., Baudat, F., Grey, C., Liskay, R.M., de Massy, B. Mol. Cell (2005) [Pubmed]
  4. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. Yan, G., Fu, Y., Faustman, D.L. J. Immunol. (1997) [Pubmed]
  5. Genomic organization and tissue expression of mouse proteasome gene Lmp-2. Zhou, P., Zanelli, E., Smart, M., David, C. Genomics (1993) [Pubmed]
  6. STAT1 regulates lipopolysaccharide- and TNF-alpha-dependent expression of transporter associated with antigen processing 1 and low molecular mass polypeptide 2 genes in macrophages by distinct mechanisms. Marqués, L., Brucet, M., Lloberas, J., Celada, A. J. Immunol. (2004) [Pubmed]
  7. DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene. Cruz, M., Elenich, L.A., Smolarek, T.A., Menon, A.G., Monaco, J.J. Genomics (1997) [Pubmed]
  8. NOD mice are defective in proteasome production and activation of NF-kappaB. Hayashi, T., Faustman, D. Mol. Cell. Biol. (1999) [Pubmed]
  9. No dosage effect of recombinational hotspots in the mouse major histocompatibility complex. Yoshino, M., Sagai, T., Lindahl, K.F., Toyoda, Y., Shiroishi, T., Moriwaki, K. Immunogenetics (1994) [Pubmed]
  10. Characterization and mapping of the gene encoding mouse proteasome subunit DELTA (Lmp19). Woodward, E.C., Monaco, J.J. Immunogenetics (1995) [Pubmed]
 
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