Gene Review:
ena - enabled protein
Xenopus laevis
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High impact information on LOC446221
- Together, these results provide evidence that Ena/VASP proteins and FAK are required for somite formation in Xenopus and support the idea that Ena/VASP and FAK function in a common pathway to regulate integrin-dependent migration and adhesion during somitogenesis [1].
- Analysis of the temporal expression of Xenopus Ena (Xena) demonstrates that multiple isoforms of Xena are detected throughout embryogenesis and that the presence of different isoforms is developmentally regulated [2].
- The Ena/VASP family of actin-binding proteins function in several cellular processes that involve dynamic regulation of the actin cytoskeleton, including axon guidance, platelet aggregation, cell migration, and cell adhesion [2].
Anatomical context of LOC446221
- Inhibition of Ena/VASP function with dominant-negative mutants results in abnormal somite formation that correlates with later defects in intermyotomal junctions [1].
- Xenopus Ena (Xena) localizes to the cell periphery in the presomitic mesoderm (PSM), and is enriched at intersomitic junctions and at myotendinous junctions in somites and the myotome, where it co-localizes with beta1-integrin, vinculin and FAK [1].
References
- Regulation of somitogenesis by Ena/VASP proteins and FAK during Xenopus development. Kragtorp, K.A., Miller, J.R. Development (2006) [Pubmed]
- Cloning and developmental expression of Xenopus Enabled (Xena). Xanthos, J.B., Wanner, S.J., Miller, J.R. Dev. Dyn. (2005) [Pubmed]
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