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Gene Review:

pk - prickle

Drosophila melanogaster

Synonyms: CG11084, CG12830, Dmel\CG11084, Pk, Pk-Sple, ...

Jenny, A. et al., Gubb, D. et al., Rawls, A.S. et al., Bastock, R. et al., Heitzler, P. et al., et al.

Gubb, Green, Huen, Coulson, Johnson, Tree, Collier, Roote,

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High impact information on pk

Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling [1].
The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs [2].
The phenotypes of pk mutants, and transgenic flies in which the different isoforms are overexpressed show that the balance between Pk and Sple is critical for the specification of planar polarity [2].
Dishevelled can also be bound by the Frizzled PCP antagonist Prickle [3].
Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding [3].

Biological context of pk

Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling [4].
Thus, asymmetric localization of Fz, Stbm and Pk define two opposite cortical domains prior to mitosis of the pI cell [5].
The prickle-related gene in vertebrates is essential for gastrulation cell movements [6].
Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster [7].

Anatomical context of pk

We show that Strabismus binds directly to Dishevelled and Prickle and is able to recruit them to membranes [8].

Physical interactions of pk

Thus our data suggest that the Stbm/Pk complex modulates Fz/Dsh activity, resulting in a symmetry-breaking step during polarity signaling [4].
Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning [8].

Regulatory relationships of pk

While neither of these proteins is required for the other's localization, Prickle localization is influenced by Strabismus function [9].

Other interactions of pk

Through this interaction, Pk affects Stbm membrane localization and can cause clustering of Stbm [4].
Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye [9].

References

Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Tree, D.R., Shulman, J.M., Rousset, R., Scott, M.P., Gubb, D., Axelrod, J.D. Cell (2002) [Pubmed]
The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb, D., Green, C., Huen, D., Coulson, D., Johnson, G., Tree, D., Collier, S., Roote, J. Genes Dev. (1999) [Pubmed]
Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding. Jenny, A., Reynolds-Kenneally, J., Das, G., Burnett, M., Mlodzik, M. Nat. Cell Biol. (2005) [Pubmed]
Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. Jenny, A., Darken, R.S., Wilson, P.A., Mlodzik, M. EMBO J. (2003) [Pubmed]
The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila. Bellaïche, Y., Beaudoin-Massiani, O., Stuttem, I., Schweisguth, F. Development (2004) [Pubmed]
The prickle-related gene in vertebrates is essential for gastrulation cell movements. Takeuchi, M., Nakabayashi, J., Sakaguchi, T., Yamamoto, T.S., Takahashi, H., Takeda, H., Ueno, N. Curr. Biol. (2003) [Pubmed]
Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster. Heitzler, P., Coulson, D., Saenz-Robles, M.T., Ashburner, M., Roote, J., Simpson, P., Gubb, D. Genetics (1993) [Pubmed]
Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning. Bastock, R., Strutt, H., Strutt, D. Development (2003) [Pubmed]
Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye. Rawls, A.S., Wolff, T. Development (2003) [Pubmed]

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