Gene Review:
cos - costa
Drosophila melanogaster
Synonyms:
CG1708, COS2, COS[2], Cos, Cos-2, ...
- Hedgehog-stimulated phosphorylation of the kinesin-related protein Costal2 is mediated by the serine/threonine kinase fused. Nybakken, K.E., Turck, C.W., Robbins, D.J., Bishop, J.M. J. Biol. Chem. (2002)
- A concerted approach to the study of the aneuploidogenic properties of two chelating agents (EDTA and NTA) in the germ and somatic cell lines of Drosophila and the mouse. Zordan, M., Russo, A., Costa, R., Bianco, N., Beltrame, C., Levis, A.G. Environ. Mol. Mutagen. (1990)
- Further characterization of the DFNA1 audiovestibular phenotype. Lalwani, A.K., Jackler, R.K., Sweetow, R.W., Lynch, E.D., Raventós, H., Morrow, J., King, M.C., León, P.E. Arch. Otolaryngol. Head Neck Surg. (1998)
- Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Robbins, D.J., Nybakken, K.E., Kobayashi, R., Sisson, J.C., Bishop, J.M., Thérond, P.P. Cell (1997)
- Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Jia, J., Tong, C., Jiang, J. Genes Dev. (2003)
- Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Wang, G., Amanai, K., Wang, B., Jiang, J. Genes Dev. (2000)
- Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused. Ho, K.S., Suyama, K., Fish, M., Scott, M.P. Development (2005)
- KIF27 is one of orthologs for Drosophila Costal-2. Katoh, Y., Katoh, M. Int. J. Oncol. (2004)
- Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Lum, L., Zhang, C., Oh, S., Mann, R.K., von Kessler, D.P., Taipale, J., Weis-Garcia, F., Gong, R., Wang, B., Beachy, P.A. Mol. Cell (2003)
- Functional domains of fused, a serine-threonine kinase required for signaling in Drosophila. Thérond, P., Alves, G., Limbourg-Bouchon, B., Tricoire, H., Guillemet, E., Brissard-Zahraoui, J., Lamour-Isnard, C., Busson, D. Genetics (1996)
- The segment polarity gene costal-2 in Drosophila. II. The origin of imaginal pattern duplications. Simpson, P., Grau, Y. Dev. Biol. (1987)
- The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner. Stegman, M.A., Goetz, J.A., Ascano, M., Ogden, S.K., Nybakken, K.E., Robbins, D.J. J. Biol. Chem. (2004)
- Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Monnier, V., Dussillol, F., Alves, G., Lamour-Isnard, C., Plessis, A. Curr. Biol. (1998)
- Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Ruel, L., Rodriguez, R., Gallet, A., Lavenant-Staccini, L., Thérond, P.P. Nat. Cell Biol. (2003)
- Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Zhang, W., Zhao, Y., Tong, C., Wang, G., Wang, B., Jia, J., Jiang, J. Dev. Cell (2005)
- Regulation of Hedgehog signaling: a complex story. Ogden, S.K., Ascano, M., Stegman, M.A., Robbins, D.J. Biochem. Pharmacol. (2004)
- The segment polarity gene costal-2 in Drosophila. I. The organization of both primary and secondary embryonic fields may be affected. Grau, Y., Simpson, P. Dev. Biol. (1987)
- Genetic and cytogenetic analysis of the 43A-E region containing the segment polarity gene costa and the cellular polarity genes prickle and spiny-legs in Drosophila melanogaster. Heitzler, P., Coulson, D., Saenz-Robles, M.T., Ashburner, M., Roote, J., Simpson, P., Gubb, D. Genetics (1993)
- Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Préat, T., Thérond, P., Limbourg-Bouchon, B., Pham, A., Tricoire, H., Busson, D., Lamour-Isnard, C. Genetics (1993)