Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Pk17E - Protein kinase-like 17E

Drosophila melanogaster

Synonyms: 3-10, BIN4, Bin4, CG7001, Dmel\CG7001, ...

Lohe, A.R. et al., Guedes, S.d.e. .M. et al., Chapman, E.R. et al., Bloomquist, J.R. et al., Belelli, D. et al.

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High impact information on Pk17E

This effect is specific for divalent cations that can stimulate exocytosis of synaptic vesicles (Ca2+ >> Ba2+, Sr2+ >> Mg2+) and occurs with an EC50 value of 3-10 microM Ca2+ [1].
Horizontal transmission, approximately 3-10 MYA, is strongly suggested by the observation that the sequence of the MLE in Drosophila erecta is 97% identical in nucleotide sequence with that of an MLE in the cat flea, Ctenocephalides felis [2].
By contrast, relatively high concentrations (3-10 microM) of this steroid had only a modest effect on the Rdl receptor and its splice variant [3].
Therefore, with the application of recent advances in proteomic analysis approaches, a protein map of D. melanogaster larvae hemolymph proteins was obtained using 2-DE in the range of pH 3-10 [4].
In susceptible preparations (n = 5), inhibition of nerve firing by 1 mM gamma-aminobutyric acid (GABA) was effectively antagonized within 3-10 min by 10 microM dieldrin [5].

References

A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization. Chapman, E.R., An, S., Edwardson, J.M., Jahn, R. J. Biol. Chem. (1996) [Pubmed]
Horizontal transmission, vertical inactivation, and stochastic loss of mariner-like transposable elements. Lohe, A.R., Moriyama, E.N., Lidholm, D.A., Hartl, D.L. Mol. Biol. Evol. (1995) [Pubmed]
Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes. Belelli, D., Callachan, H., Hill-Venning, C., Peters, J.A., Lambert, J.J. Br. J. Pharmacol. (1996) [Pubmed]
Drosophila melanogaster larval hemolymph protein mapping. Guedes, S.d.e. .M., Vitorino, R., Tomer, K., Domingues, M.R., Correia, A.J., Amado, F., Domingues, P. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
Reduced neuronal sensitivity to dieldrin and picrotoxinin in a cyclodiene-resistant strain of Drosophila melanogaster (Meigen). Bloomquist, J.R., Roush, R.T., ffrench-Constant, R.H. Arch. Insect Biochem. Physiol. (1992) [Pubmed]

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