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Gene Review

KDR  -  kinase insert domain receptor (a type III...

Canis lupus familiaris

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Disease relevance of KDR


High impact information on KDR

  • The modification of lead structures resulted in 3m which exhibited the best overall profile in KDR inhibitory activity, iv/po pharmacokinetics, and reduced hERG affinity [2].
  • VEGF also enhanced tube formation in dog endothelial cells and increased the expression of two VEGF receptors, Flt-1 and KDR/Flk-1 [3].

Other interactions of KDR

  • VEGF also increases the expression of the receptors, KDR and Flt-1, and activates the p44/42 MAP kinase pathway [3].


  1. Localization of integrin alpha(v)beta3 and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in cutaneous and oral melanomas of dog. Rawlings, N.G., Simko, E., Bebchuk, T., Caldwell, S.J., Singh, B. Histol. Histopathol. (2003) [Pubmed]
  2. Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase. Sisko, J.T., Tucker, T.J., Bilodeau, M.T., Buser, C.A., Ciecko, P.A., Coll, K.E., Fernandes, C., Gibbs, J.B., Koester, T.J., Kohl, N., Lynch, J.J., Mao, X., McLoughlin, D., Miller-Stein, C.M., Rodman, L.D., Rickert, K.W., Sepp-Lorenzino, L., Shipman, J.M., Thomas, K.A., Wong, B.K., Hartman, G.D. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  3. Vascular endothelial growth factor (VEGF) enhances the expression of receptors and activates mitogen-activated protein (MAP) kinase of dog retinal capillary endothelial cells. Murata, M., Kador, P.F., Sato, S. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2000) [Pubmed]
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