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Gene Review

KDR  -  kinase insert domain receptor (a type III...

Gallus gallus

Synonyms: FLK1, VEGFR2
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Analytical, diagnostic and therapeutic context of KDR

  • Using in situ hybridization, VEGF receptor-2 (flk-1/Quek1) and the homologous flt-4 (Quek2) receptor were studied in the CAM of normal quail embryos and after VEGF(121) application on the CAM of 11-day-old quail embryos [7].
  • The similarity of action of matrix-bound L1Ig6 and soluble VEGF-A165 indicate a close link between specific ligation of alphavbeta3-integrin and VEGF-R2 and suggest the possible use of matrix-bound L1Ig6 in local therapeutic angiogenesis [2].


  1. Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. Jaffredo, T., Gautier, R., Eichmann, A., Dieterlen-Lièvre, F. Development (1998) [Pubmed]
  2. Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2. Hall, H., Hubbell, J.A. Microvasc. Res. (2004) [Pubmed]
  3. In situ hybridization and immunogold localization of vascular endothelial growth factor receptor-2 on the pericytes of the chick chorioallantoic membrane. Ribatti, D., Cruz, A., Nico, B., Favier, J., Vacca, A., Corsi, P., Roncali, L., Dammacco, F. Cytokine (2002) [Pubmed]
  4. Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development of the vascular system in the chick embryo bursa of Fabricius. Ribatti, D., De Falco, G., Vacca, A., Nico, B., Errede, M., Roccaro, A.M., Roncali, L., Dammacco, F. Int. J. Mol. Med. (2001) [Pubmed]
  5. On the mechanism(s) of thrombin induced angiogenesis. Maragoudakis, M.E., Tsopanoglou, N.E. Adv. Exp. Med. Biol. (2000) [Pubmed]
  6. Expression of the Flk1 receptor and its ligand VEGF in the developing chick central nervous system. Hashimoto, T., Zhang, X.M., Yang, X.J. Gene Expr. Patterns (2003) [Pubmed]
  7. VEGF121 induces proliferation of vascular endothelial cells and expression of flk-1 without affecting lymphatic vessels of chorioallantoic membrane. Wilting, J., Birkenhäger, R., Eichmann, A., Kurz, H., Martiny-Baron, G., Marmé, D., McCarthy, J.E., Christ, B., Weich, H.A. Dev. Biol. (1996) [Pubmed]
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