The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

KDR  -  kinase insert domain receptor

Bos taurus

Synonyms: VEGFR2, flk-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of flk-1


High impact information on flk-1


Biological context of flk-1


Anatomical context of flk-1


Associations of flk-1 with chemical compounds


Other interactions of flk-1


Analytical, diagnostic and therapeutic context of flk-1


  1. Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells. Davie, N.J., Crossno, J.T., Frid, M.G., Hofmeister, S.E., Reeves, J.T., Hyde, D.M., Carpenter, T.C., Brunetti, J.A., McNiece, I.K., Stenmark, K.R. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  2. Activation of EphB2 and its ligands promotes vascular smooth muscle cell proliferation. Woods, T.C., Blystone, C.R., Yoo, J., Edelman, E.R. J. Biol. Chem. (2002) [Pubmed]
  3. Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Mandriota, S.J., Pyke, C., Di Sanza, C., Quinodoz, P., Pittet, B., Pepper, M.S. Am. J. Pathol. (2000) [Pubmed]
  4. Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. He, H., Venema, V.J., Gu, X., Venema, R.C., Marrero, M.B., Caldwell, R.B. J. Biol. Chem. (1999) [Pubmed]
  5. Insulin and interleukin-4 induce desensitization to the mitogenic effects of insulin-like growth factor-I. Pivotal role for insulin receptor substrate-2. Haddad, T.C., Conover, C.A. J. Biol. Chem. (1997) [Pubmed]
  6. Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. Patterson, C., Perrella, M.A., Hsieh, C.M., Yoshizumi, M., Lee, M.E., Haber, E. J. Biol. Chem. (1995) [Pubmed]
  7. Involvement of nerve growth factor in the ovulatory cascade: trkA receptor activation inhibits gap junctional communication between thecal cells. Mayerhofer, A., Dissen, G.A., Parrott, J.A., Hill, D.F., Mayerhofer, D., Garfield, R.E., Costa, M.E., Skinner, M.K., Ojeda, S.R. Endocrinology (1996) [Pubmed]
  8. Effect of glycation on basic fibroblast growth factor induced angiogenesis and activation of associated signal transduction pathways in vascular endothelial cells: possible relevance to wound healing in diabetes. Duraisamy, Y., Slevin, M., Smith, N., Bailey, J., Zweit, J., Smith, C., Ahmed, N., Gaffney, J. Angiogenesis (2001) [Pubmed]
  9. Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. Mandriota, S.J., Menoud, P.A., Pepper, M.S. J. Biol. Chem. (1996) [Pubmed]
  10. Expression of vascular endothelial growth factor (VEGF) and its corresponding receptors (flt-1 and flk-1) in the bovine oviduct. Gabler, C., Einspanier, A., Schams, D., Einspanier, R. Mol. Reprod. Dev. (1999) [Pubmed]
  11. Role of protein tyrosine kinase on regulation of trabecular meshwork and ciliary muscle contractility. Wiederholt, M., Groth, J., Strauss, O. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  12. Direct effects of nerve growth factor on thecal cells from antral ovarian follicles. Dissen, G.A., Parrott, J.A., Skinner, M.K., Hill, D.F., Costa, M.E., Ojeda, S.R. Endocrinology (2000) [Pubmed]
  13. Vascular endothelial growth factor and its receptors. Neufeld, G., Tessler, S., Gitay-Goren, H., Cohen, T., Levi, B.Z. Prog. Growth Factor Res. (1994) [Pubmed]
  14. Hormonal regulation of mitogen-activated protein kinase activity in bovine adrenocortical cells: cross-talk between phosphoinositides, adenosine 3',5'-monophosphate, and tyrosine kinase receptor pathways. Chabre, O., Cornillon, F., Bottari, S.P., Chambaz, E.M., Vilgrain, I. Endocrinology (1995) [Pubmed]
  15. Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells. Cheng, J.J., Huang, N.K., Chang, T.T., Wang, D.L., Lu, M.K. Life Sci. (2005) [Pubmed]
  16. Inhibition of vascular smooth muscle cell proliferation by a novel fibroblast growth factor receptor antagonist. Segev, A., Aviezer, D., Safran, M., Gross, Z., Yayon, A. Cardiovasc. Res. (2002) [Pubmed]
  17. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Hase, A., Saito, F., Yamada, H., Arai, K., Shimizu, T., Matsumura, K. J. Neurochem. (2005) [Pubmed]
WikiGenes - Universities