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HSD3B2  -  hydroxy-delta-5-steroid dehydrogenase, 3...

Canis lupus familiaris

Synonyms: 3b-HSD, HSD3B, HSD3B1
 
 
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High impact information on HSD3B1

  • These neurones express 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), P450 side-chain cleavage (P450scc), 17 alpha-hydroxylase/c17, 20lyase (P450c17), P450 aromatase (P450arom) and produce pregnenolone, progesterone, dehydroepiandrosterone, androstenedion, oestradion and oestrone [1].
  • In this study we have examined the distribution of 3 beta-HSD and CNPase by immunohistochemistry using monoclonal antibody in canine cerebellar cortex [1].
  • Yet, these positive reactions of SCC and 3 beta-HSD in the marginal region of the CL disappeared in the late-stage of gestation [2].
  • Functional 3 beta-hydroxysteroid dehydrogenase coupled with isomerase (3 beta-HSD) was extracted from dog pancreatic mitochondria by treatment with the zwitterionic detergent CHAPSO [3].
  • Treatment of the mitochondrial suspension with sodium deoxycholate, CTAB, Lubrol XW, Brij 58, Emulgen 913 and Triton X-100 markedly decreased the 3 beta-HSD activities as a function of the detergent concentration and failed in to achieve solubilization [3].
 

Associations of HSD3B1 with chemical compounds

  • In the light microscope the neo-synthesis of progesterone in the c.l.-tissue can be made visible by histochemical demonstration of the activity of Delta(5)-3 beta-hydroxysteroiddehydrogenase (3 beta-HSD) only up to a progesterone level exceeding 6.7 ng/ml plasma [4].
  • The androgen precursors, convertase SCC and 3 beta-HSD, were confirmed in all regions of the CL during the mid-stage of gestation (day 40), showing particularly strong cell reactions in the marginal region of the CL [2].

References

  1. Neurosteroidogenesis in oligodendrocytes and Purkinje neurones of cerebellar cortex of dogs. Yarim, M., Kabakci, N. Anatomia, histologia, embryologia. (2004) [Pubmed]
  2. Immunohistochemical study of steroidogenic enzymes in the ovary and placenta during pregnancy in the dog. Nishiyama, T., Tsumagari, S., Ito, M., Kimura, J., Watanabe, G., Taya, K., Takeishi, M. Anatomia, histologia, embryologia. (1999) [Pubmed]
  3. Detergent solubilization of 3 beta-hydroxysteroid dehydrogenase from dog pancreas. Mendoza-Hernández, G., Libreros-Minotta, C.A., Rendón, J.L. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1996) [Pubmed]
  4. The corpus luteum periodicum in the bitch: histochemical and biochemical investigations during different phases of the cycle. Dreier, K.H., Choi, H.S., Hager, H. Histochemistry (1975) [Pubmed]
 
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