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Chemical Compound Review

chapso     3-[dimethyl-[3-[[(4R)-4- [(3R,5S,7R,8S,9S...

Synonyms: C3649_SIGMA, C4695_SIGMA, AR-1F1188, FT-0623583, AC1L3U2M, ...
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Disease relevance of


High impact information on

  • CXCR4 was found to multimerize in cell lysates containing the detergents CHAPSO or Cymal-7 but not other detergents that have been shown to disrupt the native conformation of CXCR4 [2].
  • Purple membrane was solubilized in Triton X-100 and BR was purified by size exclusion chromatography using 3-[cholamidopropyl)dimethylammonio]-2-hydroxyl-1-propanesulfonic acid (CHAPSO) detergent at pH 5 [3].
  • The muscarinic receptor from the cerebral cortex, heart, and lacrimal gland can be solubilized in the zwitterionic detergent 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propane sulfonate (CHAPSO) with retention of high affinity [3H]N-methyls-copolamine binding [4].
  • These inhibitor derivatives bound and precipitated PS1 fragments from membrane CHAPSO extracts [5].
  • Our experiments provide the basis for studying the thermodynamic stability of sbR by evaluating reversible folding and unfolding conditions in DMPC/CHAPSO/SDS mixed micelles [1].

Biological context of


Anatomical context of

  • Dopamine receptor binding proteins were solubilized with the detergent 3-(3-cholamidopropyl) dimethylammonio-2-hydroxy-1-propanesulfonate (CHAPSO) from bovine and rat striatal membranes [8].
  • Disruption of the microsomes by Chapso or by ultrasonication markedly enhanced the thermolability of the mannose-6-phosphatase activity [9].
  • A specific receptor for the brain-gut neuropeptide pituitary adenylate-cyclase-activating polypeptide (PACAP-1 receptor) was solubilized with Chapso from porcine brain plasma membranes and purified [10].
  • Complete disruption of rat liver microsomes was achieved by incubation for 60 min at 0 degree C in the presence of 4 mM zwitterionic detergent 3-[(3-cholamido-propyl)dimethyl-ammonio]-2-hydroxy-1-propane sulphonate (Chapso) [9].
  • Functional 3 beta-hydroxysteroid dehydrogenase coupled with isomerase (3 beta-HSD) was extracted from dog pancreatic mitochondria by treatment with the zwitterionic detergent CHAPSO [11].

Associations of with other chemical compounds


Gene context of


Analytical, diagnostic and therapeutic context of


  1. Probing the folding and unfolding of wild-type and mutant forms of bacteriorhodopsin in micellar solutions: evaluation of reversible unfolding conditions. Chen, G.Q., Gouaux, E. Biochemistry (1999) [Pubmed]
  2. Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor. Babcock, G.J., Farzan, M., Sodroski, J. J. Biol. Chem. (2003) [Pubmed]
  3. Purification of bacteriorhodopsin and characterization of mature and partially processed forms. Miercke, L.J., Ross, P.E., Stroud, R.M., Dratz, E.A. J. Biol. Chem. (1989) [Pubmed]
  4. Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate. Poyner, D.R., Birdsall, N.J., Curtis, C., Eveleigh, P., Hulme, E.C., Pedder, E.K., Wheatley, M. Mol. Pharmacol. (1989) [Pubmed]
  5. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex. Evin, G., Canterford, L.D., Hoke, D.E., Sharples, R.A., Culvenor, J.G., Masters, C.L. Biochemistry (2005) [Pubmed]
  6. Effects of Asp-96----Asn, Asp-85----Asn, and Arg-82----Gln single-site substitutions on the photocycle of bacteriorhodopsin. Thorgeirsson, T.E., Milder, S.J., Miercke, L.J., Betlach, M.C., Shand, R.F., Stroud, R.M., Kliger, D.S. Biochemistry (1991) [Pubmed]
  7. Solubilization of binding sites for IAPP and CGRP from rat lung. Bhogal, R., Smith, D.M., Bloom, S.R. Peptides (1994) [Pubmed]
  8. Solubilization and characterization of striatal dopamine receptors. Lew, J.Y., Goldstein, M. J. Neurochem. (1984) [Pubmed]
  9. Assay of mannose-6-phosphatase in untreated and detergent-disrupted rat-liver microsomes for assessment of integrity of microsomal preparations. Vanstapel, F., Pua, K., Blanckaert, N. Eur. J. Biochem. (1986) [Pubmed]
  10. Characterization and purification of the solubilized pituitary adenylate-cyclase-activating polypeptide-1 receptor from porcine brain using a biotinylated ligand. Schäfer, H., Schmidt, W.E. Eur. J. Biochem. (1993) [Pubmed]
  11. Detergent solubilization of 3 beta-hydroxysteroid dehydrogenase from dog pancreas. Mendoza-Hernández, G., Libreros-Minotta, C.A., Rendón, J.L. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1996) [Pubmed]
  12. Reconstitution of membrane proteins into lipid-rich bilayered mixed micelles for NMR studies. Sanders, C.R., Landis, G.C. Biochemistry (1995) [Pubmed]
  13. Photoactivation of rhodopsin and interaction with transducin in detergent micelles. Effect of 'doping' with steroid molecules. König, B., Welte, W., Hofmann, K.P. FEBS Lett. (1989) [Pubmed]
  14. Quantitative determination of zwitterionic detergents using salt-induced phase separation of Triton X-100. Fricke, B. Anal. Biochem. (2000) [Pubmed]
  15. Alzheimer amyloid precursor aspartyl proteinase activity in CHAPSO homogenates of Spodoptera frugiperda cells. Carter, T.L., Verdile, G., Groth, D., Bogush, A., Thomas, S., Shen, P., Fraser, P.E., Mathews, P., Nixon, R.A., Ehrlich, M.E., Kwok, J.B., St George-Hyslop, P., Schofield, P., Li, Y., Yang, A., Martins, R.N., Gandy, S. Alzheimer disease and associated disorders. (2004) [Pubmed]
  16. Immunorecognition in the freshwater bivalve, Corbicula fluminea. I. Electrophoretic and immunologic analyses of opsonic plasma components. Yang, R., Yoshino, T.P. Dev. Comp. Immunol. (1990) [Pubmed]
  17. Characterization of 19-nor-10-oxo-25-hydroxyvitamin D3 production by solubilized chick kidney mitochondria and bovine serum albumin. Tran, J.M., Henry, H.L. J. Steroid Biochem. (1989) [Pubmed]
  18. Solid state 13C NMR of unlabeled phosphatidylcholine bilayers: spectral assignments and measurement of carbon-phosphorus dipolar couplings and 13C chemical shift anisotropies. Sanders, C.R. Biophys. J. (1993) [Pubmed]
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